1,1-dimethylethyl 6-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

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Chemical Name:1,1-dimethylethyl 6-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate
CAS No.:912846-31-2
Molecular Formula:C₂₆H₃₁N₃O₅
Molecular Weight:465.549
Hs Code.:

Synonyms:1,1-dimethylethyl 6-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

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Chemical Property of 1,1-dimethylethyl 6-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

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Technology Process of 1,1-dimethylethyl 6-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

There total 5 articles about 1,1-dimethylethyl 6-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 912846-30-1
1,1-dimethylethyl 6-[(N-{[(phenylmethyl)oxy]carbonyl}-L-methionyl)amino]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

: 912846-31-2
1,1-dimethylethyl 6-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: methyl iodide / acetonitrile / 20 °C

2: caesium carbonate / acetonitrile / 60 °C

With caesium carbonate; methyl iodide; In acetonitrile;
DOI:10.1016/j.bmcl.2011.01.129

Reference yield:

: C₂₈H₃₈N₃O₅S⁽¹⁺⁾*I^(1-)

: 912846-31-2
1,1-dimethylethyl 6-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: With caesium carbonate; In acetonitrile; at 60 ℃;
DOI:10.1016/j.bmcl.2011.01.129

Reference yield:

: 164148-92-9
tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 912846-31-2
1,1-dimethylethyl 6-[(3S)-2-oxo-3-({[(phenylmethyl)oxy]carbonyl}amino)-1-pyrrolidinyl]-3,4-dihydro-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 20 °C

2: methyl iodide / acetonitrile / 20 °C

3: caesium carbonate / acetonitrile / 60 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; methyl iodide; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2011.01.129