(S)-2-Benzenesulfonyl-4-benzyloxy-1,4-bis-[(2S,5S,2'S,5'S)-5'-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-yl]-butan-1-ol

Base Information

Chemical Name:(S)-2-Benzenesulfonyl-4-benzyloxy-1,4-bis-[(2S,5S,2'S,5'S)-5'-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-yl]-butan-1-ol
CAS No.:195731-43-2
Molecular Formula:C₆₇H₈₄O₁₀SSi₂
Molecular Weight:1137.63
Hs Code.:

Synonyms:(S)-2-Benzenesulfonyl-4-benzyloxy-1,4-bis-[(2S,5S,2'S,5'S)-5'-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-yl]-butan-1-ol

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Chemical Property of (S)-2-Benzenesulfonyl-4-benzyloxy-1,4-bis-[(2S,5S,2'S,5'S)-5'-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-yl]-butan-1-ol

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Technology Process of (S)-2-Benzenesulfonyl-4-benzyloxy-1,4-bis-[(2S,5S,2'S,5'S)-5'-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-yl]-butan-1-ol

There total 8 articles about (S)-2-Benzenesulfonyl-4-benzyloxy-1,4-bis-[(2S,5S,2'S,5'S)-5'-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-yl]-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157732-26-8
(2S,5S,2'S,5'S)-5-<5'-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2'-yl>tetrahydrofuran-2-carboxaldehyde

: 157732-28-0
(all-S)-phenyl-<3-benzyloxy-3-<5'-(5''-tert-butyldiphenylsiloxymethyltetrahydrofuran-2''-yl)-tetrahydrofuran-2'-yl>propyl>sulfone

: 195731-43-2
(S)-2-Benzenesulfonyl-4-benzyloxy-1,4-bis-[(2S,5S,2'S,5'S)-5'-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-yl]-butan-1-ol

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 5h;
DOI:10.1002/chem.19970030723

Reference yield:

: 100-39-0
benzyl bromide

: 195731-43-2
(S)-2-Benzenesulfonyl-4-benzyloxy-1,4-bis-[(2S,5S,2'S,5'S)-5'-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-yl]-butan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: NaH / tetrahydrofuran / 6 h / 45 °C

2: 1.) O₃, 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C, 2.) -78 deg C to r.t., 1 h

3: 99 percent / NaBH₄ / methanol / 0.5 h

4: 90 percent / pyridine, tri-n-butylphosphine / CH₂Cl₂ / 1 h

5: 76 percent / magnesium monoperoxophthalate / ethanol / 0.5 h / 20 °C

6: LDA / tetrahydrofuran; hexane / 5 h / -78 - 0 °C

With pyridine; sodium tetrahydroborate; tributylphosphine; sodium hydride; magnesium monoperoxyphthalate hexahydrate; ozone; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane;
DOI:10.1002/chem.19970030723

Reference yield:

: 157732-26-8
(2S,5S,2'S,5'S)-5-<5'-<(tert-Butyldiphenylsiloxy)methyl>tetrahydrofuran-2'-yl>tetrahydrofuran-2-carboxaldehyde

: 195731-43-2
(S)-2-Benzenesulfonyl-4-benzyloxy-1,4-bis-[(2S,5S,2'S,5'S)-5'-(tert-butyl-diphenyl-silanyloxymethyl)-octahydro-[2,2']bifuranyl-5-yl]-butan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

2: NaH / tetrahydrofuran / 6 h / 45 °C

3: 1.) O₃, 2.) PPh₃ / 1.) CH₂Cl₂, -78 deg C, 2.) -78 deg C to r.t., 1 h

4: 99 percent / NaBH₄ / methanol / 0.5 h

5: 90 percent / pyridine, tri-n-butylphosphine / CH₂Cl₂ / 1 h

6: 76 percent / magnesium monoperoxophthalate / ethanol / 0.5 h / 20 °C

7: LDA / tetrahydrofuran; hexane / 5 h / -78 - 0 °C

With pyridine; sodium tetrahydroborate; tributylphosphine; sodium hydride; magnesium monoperoxyphthalate hexahydrate; ozone; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane;
DOI:10.1002/chem.19970030723