(±)-2-fluorophenyl 2-(6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate

Base Information

Chemical Name:(±)-2-fluorophenyl 2-(6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate
CAS No.:1609137-80-5
Molecular Formula:C₂₉H₂₃FN₂O₂
Molecular Weight:450.512
Hs Code.:

Synonyms:(±)-2-fluorophenyl 2-(6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate

Suppliers and Price of (±)-2-fluorophenyl 2-(6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (±)-2-fluorophenyl 2-(6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (±)-2-fluorophenyl 2-(6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate

There total 4 articles about (±)-2-fluorophenyl 2-(6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1609137-79-2
(±)-2-fluorophenyl 2-(8-amino-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate

: 1609137-80-5
(±)-2-fluorophenyl 2-(6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate

Guidance literature:: (±)-2-fluorophenyl 2-(8-amino-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With phosphoric acid; In water; at 24 ℃; for 25h;
DOI:10.1002/chem.201304810

Reference yield:

: 1609137-83-8
(±)-2-fluorophenyl 3-methyl-2-(8-nitro-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)benzoate

: 1609137-80-5
(±)-2-fluorophenyl 2-(6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / ethyl acetate; methanol / 24 h / 24 °C

2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

2.2: 25 h / 24 °C

With hydrogenchloride; hydrogen; sodium nitrite; In methanol; water; ethyl acetate;
DOI:10.1002/chem.201304810

Reference yield:

: 3-methyl-2-(8-nitro-6H,12H-5,11-methano-dibenzo[b,f][1,5]diazocin-2-yl)-benzoic acid

: 1609137-80-5
(±)-2-fluorophenyl 2-(6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 22 h / 24 °C / Inert atmosphere

2.1: hydrogen / ethyl acetate; methanol / 24 h / 24 °C

3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

3.2: 25 h / 24 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; sodium nitrite; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1002/chem.201304810