(±)-2-fluorophenyl 3-methyl-2-(8-nitro-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)benzoate

Base Information

Chemical Name:(±)-2-fluorophenyl 3-methyl-2-(8-nitro-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)benzoate
CAS No.:1609137-83-8
Molecular Formula:C₂₉H₂₂FN₃O₄
Molecular Weight:495.51
Hs Code.:

Synonyms:(±)-2-fluorophenyl 3-methyl-2-(8-nitro-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)benzoate

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Chemical Property of (±)-2-fluorophenyl 3-methyl-2-(8-nitro-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)benzoate

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Technology Process of (±)-2-fluorophenyl 3-methyl-2-(8-nitro-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)benzoate

There total 1 articles about (±)-2-fluorophenyl 3-methyl-2-(8-nitro-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 367-12-4
2-fluorophenol

: 3-methyl-2-(8-nitro-6H,12H-5,11-methano-dibenzo[b,f][1,5]diazocin-2-yl)-benzoic acid

: 1609137-83-8
(±)-2-fluorophenyl 3-methyl-2-(8-nitro-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)benzoate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 24 ℃; for 22h; Inert atmosphere;
DOI:10.1002/chem.201304810

Reference yield: 52.0%

: 1609137-83-8
(±)-2-fluorophenyl 3-methyl-2-(8-nitro-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)benzoate

: 1609137-79-2
(±)-2-fluorophenyl 2-(8-amino-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate

Guidance literature:: With hydrogen; In methanol; ethyl acetate; at 24 ℃; for 24h;
DOI:10.1002/chem.201304810

Reference yield:

: 1609137-83-8
(±)-2-fluorophenyl 3-methyl-2-(8-nitro-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)benzoate

: 1609137-80-5
(±)-2-fluorophenyl 2-(6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocin-2-yl)-3-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / ethyl acetate; methanol / 24 h / 24 °C

2.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

2.2: 25 h / 24 °C

With hydrogenchloride; hydrogen; sodium nitrite; In methanol; water; ethyl acetate;
DOI:10.1002/chem.201304810