N-[1-[3-(p-methylphenyl)isoxazol-5-yl]-3-methyl]butyl-(2R)-2-tert-butoxycarbonylmethylhexanamide

Base Information

Chemical Name:N-[1-[3-(p-methylphenyl)isoxazol-5-yl]-3-methyl]butyl-(2R)-2-tert-butoxycarbonylmethylhexanamide
CAS No.:1240190-32-2
Molecular Formula:C₂₇H₄₀N₂O₄
Molecular Weight:456.626
Hs Code.:

Synonyms:N-[1-[3-(p-methylphenyl)isoxazol-5-yl]-3-methyl]butyl-(2R)-2-tert-butoxycarbonylmethylhexanamide

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Chemical Property of N-[1-[3-(p-methylphenyl)isoxazol-5-yl]-3-methyl]butyl-(2R)-2-tert-butoxycarbonylmethylhexanamide

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Technology Process of N-[1-[3-(p-methylphenyl)isoxazol-5-yl]-3-methyl]butyl-(2R)-2-tert-butoxycarbonylmethylhexanamide

There total 8 articles about N-[1-[3-(p-methylphenyl)isoxazol-5-yl]-3-methyl]butyl-(2R)-2-tert-butoxycarbonylmethylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1240190-29-7
3-methyl-1-[3-(p-methylphenyl)isoxazol-5-yl]butan-1-amine

: 200866-61-1
(R)-(+)-2-butylbutanedioic acid 4-tert-butyl monoester

: 1240190-32-2
N-[1-[3-(p-methylphenyl)isoxazol-5-yl]-3-methyl]butyl-(2R)-2-tert-butoxycarbonylmethylhexanamide

Guidance literature:: (R)-(+)-2-butylbutanedioic acid 4-tert-butyl monoester; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In dichloromethane; at -5 - 0 ℃; for 4h;

3-methyl-1-[3-(p-methylphenyl)isoxazol-5-yl]butan-1-amine; In dichloromethane; at -5 - 20 ℃;
DOI:10.1007/s12272-010-0605-7

Reference yield:

: 3235-02-7,3717-15-5,3717-16-6,140461-26-3,140461-27-4
p-methylbenzaldehyde oxime

: 1240190-32-2
N-[1-[3-(p-methylphenyl)isoxazol-5-yl]-3-methyl]butyl-(2R)-2-tert-butoxycarbonylmethylhexanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-chloro-succinimide / dichloromethane / 0.67 h / 20 °C

1.2: 4 h / Reflux

2.1: pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

3.1: iodine; magnesium / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

3.2: 13 h / 20 °C / Inert atmosphere; Cooling with ice

3.3: Inert atmosphere

4.1: triethylamine / dichloromethane / 6 h / 0 - 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 5 h / 20 °C

6.1: water; ammonium chloride; zinc / ethanol / 0.5 h / Reflux

7.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / dichloromethane / 4 h / -5 - 0 °C

7.2: -5 - 20 °C

With 4-methyl-morpholine; N-chloro-succinimide; sodium azide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; water; iodine; ammonium chloride; magnesium; triethylamine; pyridinium chlorochromate; zinc; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s12272-010-0605-7

Reference yield:

: C₁₅H₁₈N₄O

: 1240190-32-2
N-[1-[3-(p-methylphenyl)isoxazol-5-yl]-3-methyl]butyl-(2R)-2-tert-butoxycarbonylmethylhexanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; ammonium chloride; zinc / ethanol / 0.5 h / Reflux

2.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / dichloromethane / 4 h / -5 - 0 °C

2.2: -5 - 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; water; ammonium chloride; zinc; In ethanol; dichloromethane;
DOI:10.1007/s12272-010-0605-7