6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

Base Information

Chemical Name:6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one
CAS No.:1432436-13-9
Molecular Formula:C₁₈H₁₅FN₄O
Molecular Weight:322.342
Hs Code.:

Synonyms:6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

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Chemical Property of 6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

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Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

There total 3 articles about 6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392081-37-6
4-(4-(chloromethyl)-3-fluorophenyl)-1-methyl-1H-pyrazole

: 40107-93-5
6,7-dihydro-5H-pyrrolo<3,4-b>pyridin-5-one

: 1432436-13-9
6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

Guidance literature:: 6,7-dihydro-5H-pyrrolo<3,4-b>pyridin-5-one; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

4-(4-(chloromethyl)-3-fluorophenyl)-1-methyl-1H-pyrazole; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

Reference yield:

: 188582-62-9
4-bromo-2-fluorobenzyl alcohol

: 1432436-13-9
6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.17 h / 160 °C / Sealed tube; Microwave irradiation

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

3.2: 1.5 h / 20 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium hydride; caesium carbonate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1418201-67-8
4-(4-hydroxymethyl-3-fluorophenyl)-1-methyl-1H-pyrazole

: 1432436-13-9
6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 2 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

2.2: 1.5 h / 20 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;