40107-93-5

Usage

Uses

Used in Pharmaceutical Industry:
6,7-dihydropyrrolo[3,4-b]pyridin-5-one is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its distinctive bicyclic structure allows for the creation of a wide range of molecules with potential therapeutic properties.
Used in Drug Discovery and Development:
6,7-dihydropyrrolo[3,4-b]pyridin-5-one is utilized as a dihydrogenase inhibitor, a role that is being explored for its implications in drug discovery and development. Its ability to inhibit specific enzymes may contribute to the treatment of certain diseases by modulating biological pathways.
Used in Materials Science:
Due to its unique structure and reactivity, 6,7-dihydropyrrolo[3,4-b]pyridin-5-one is used in the development of novel materials. Its properties make it a valuable molecule for creating new materials with specialized characteristics for use in various applications within the field of materials science.

Upstream product

• 115012-09-4 6,7-Dihydro-7-hydroxy-5H-pyrrolo<3,4-b>pyridin-5-one 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 
• 4664-00-0 2,3-pyridinedicarboximide 
• 1612756-29-2 2-(azidomethyl)nicotinic acid imidazolide 

Downstream Products

• 1432436-13-9 6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one 
• 1432436-16-2 6-(4-bromo-2-fluorobenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one 

Relevant academic research and scientific papers

RNA Cloaking by Reversible Acylation

We describe a selective and mild chemical approach for controlling RNA hybridization, folding, and enzyme interactions. Reaction of RNAs in aqueous buffer with an azide-substituted acylating agent (100–200 mm) yields several 2′-OH acylations per RNA strand in as little as 10 min. This poly-acylated (“cloaked”) RNA is strongly blocked from hybridization with complementary nucleic acids, from cleavage by RNA-processing enzymes, and from folding into active aptamer structures. Importantly, treatment with a water-soluble phosphine triggers a Staudinger reduction of the azide groups, resulting in spontaneous loss of acyl groups (“uncloaking”). This fully restores RNA folding and biochemical activity.

New artificial fluoro-cofactor of hydride transfer with novel fluorescence assay for redox biocatalysis

A new artificial fluoro-cofactor was developed for the replacement of natural cofactors NAD(P), exhibiting a high hydride transfer ability. More importantly, we established a new and fast screening method for the evaluation of the properties of artificial cofactors based on the fluorescence assay and visible color change.

Pyridine salt / 1,4-dihydropyridine derivative and preparation method thereof

The present invention discloses a pyridine salt / 1,4-dihydropyridine derivative (NAD / NADH analog) with novel structure. The NAD / NADH analog can substitute natural NAD / NADH to be applied to a biochemical system for redox reactions, and can also be used as an electron carrier for the energy transfer of an enzymatic fuel cell. Further, the NAD / NADH analogs provided by the invention are easy to prepare, isolate and purify, and have a high yield.

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogues of nicotinamide. Biological data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.

The Thermally-Controlled Chemoselective Reduction of 5H-Pyrrolopyridine-5,7(6H)-dione with Sodium Borohydride

The title reaction produced either 2-(hydroxymethyl)nicotinamide or 6,7-dihydro-7-hydroxy-5H-pyrrolopyridin-5-one as the major product at room temperature or -20 deg C, respectively, along with the corresponding regioisomers as minor products.These novel compounds were converted to known compounds in order to establish their isomeric structures.