40107-93-5

Basic information

• Product Name: 6,7-dihydropyrrolo[3,4-b]pyridin-5-one
• Synonyms: 6,7-dihydropyrrolo[3,4-b]pyridin-5-one;5H-Pyrrolo[3,4-b]pyridin-5-one, 6,7-dihydro-;6,7-Dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;6,7-Dihydro-5-oxo-5H-pyrrolo[3,4-b]pyridine;2-(Aminomethyl)nicotinic acid lactam;5,7-Dihydropyrrolo[3,4-b]pyridin-5-one
• CAS NO: 40107-93-5
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.13534
• EINECS: 251-156-6
• Mol File: 40107-93-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 204 °C(Solv: ethanol (64-17-5))
• Boiling Point: 412.125 °C at 760 mmHg
• Flash Point: 203.046 °C
• Appearance: /
• Density: 1.286 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.40±0.20(Predicted)
• CAS DataBase Reference: 6,7-dihydropyrrolo[3,4-b]pyridin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-dihydropyrrolo[3,4-b]pyridin-5-one(40107-93-5)
• EPA Substance Registry System: 6,7-dihydropyrrolo[3,4-b]pyridin-5-one(40107-93-5)

Safety Data

• Hazardous Substances Data: 40107-93-5(Hazardous Substances Data)

Usage

General Description

6,7-dihydropyrrolo[3,4-b]pyridin-5-one is a chemical compound with a bicyclic structure containing a pyrrole and a pyridine ring fused together. It is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. 6,7-dihydropyrrolo[3,4-b]pyridin-5-one has also been studied for its potential biological activities, such as its role as a dihydrogenase inhibitor, which could have implications in drug discovery and development. Additionally, 6,7-dihydropyrrolo[3,4-b]pyridin-5-one has shown promise in the development of novel materials due to its unique structure and reactivity, making it an important molecule in the field of organic chemistry and materials science.

Upstream product

• 1612756-29-2 2-(azidomethyl)nicotinic acid imidazolide 
• 115012-09-4 6,7-Dihydro-7-hydroxy-5H-pyrrolo<3,4-b>pyridin-5-one 
• 4664-00-0 2,3-pyridinedicarboximide 
• 89-00-9 Pyridine-2,3-dicarboxylic acid 

Downstream Products

• 1432436-16-2 6-(4-bromo-2-fluorobenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one 
• 1432436-13-9 6-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one 

Relevant articles and documents

RNA Cloaking by Reversible Acylation

We describe a selective and mild chemical approach for controlling RNA hybridization, folding, and enzyme interactions. Reaction of RNAs in aqueous buffer with an azide-substituted acylating agent (100–200 mm) yields several 2′-OH acylations per RNA strand in as little as 10 min. This poly-acylated (“cloaked”) RNA is strongly blocked from hybridization with complementary nucleic acids, from cleavage by RNA-processing enzymes, and from folding into active aptamer structures. Importantly, treatment with a water-soluble phosphine triggers a Staudinger reduction of the azide groups, resulting in spontaneous loss of acyl groups (“uncloaking”). This fully restores RNA folding and biochemical activity.

New artificial fluoro-cofactor of hydride transfer with novel fluorescence assay for redox biocatalysis

A new artificial fluoro-cofactor was developed for the replacement of natural cofactors NAD(P), exhibiting a high hydride transfer ability. More importantly, we established a new and fast screening method for the evaluation of the properties of artificial cofactors based on the fluorescence assay and visible color change.

The Thermally-Controlled Chemoselective Reduction of 5H-Pyrrolopyridine-5,7(6H)-dione with Sodium Borohydride

The title reaction produced either 2-(hydroxymethyl)nicotinamide or 6,7-dihydro-7-hydroxy-5H-pyrrolopyridin-5-one as the major product at room temperature or -20 deg C, respectively, along with the corresponding regioisomers as minor products.These novel compounds were converted to known compounds in order to establish their isomeric structures.