Ethyl 3-amino-3-(3-fluorophenyl)propanoate hydrochloride

Base Information

Chemical Name:Ethyl 3-amino-3-(3-fluorophenyl)propanoate hydrochloride
CAS No.:182199-73-1
Molecular Formula:C₁₁H₁₄FNO₂*ClH
Molecular Weight:247.697
Hs Code.:
DSSTox Substance ID:DTXSID30586206

Synonyms:182199-73-1;ethyl 3-amino-3-(3-fluorophenyl)propanoate hydrochloride;ethyl 3-amino-3-(3-fluorophenyl)propanoate;hydrochloride;SCHEMBL7339173;3-amino-3-(3-fluorophenyl)-propionicacid ethyl ester HCl;DTXSID30586206;3-Amino-3-(3-fluoro-phenyl)-propionic acid ethyl ester HCl;MFCD02663286;AKOS001475894;DB-304444;3-Amino-3-(3-fluoro-phenyl)-propionic acid ethyl ester hydrochloride;Ethyl 3-amino-3-(3-fluorophenyl)propanoate--hydrogen chloride (1/1)

Suppliers and Price of Ethyl 3-amino-3-(3-fluorophenyl)propanoate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL 3-AMINO-3-(3-FLUOROPHENYL)PROPANOATE HYDROCHLORIDE 95.00%
5MG
$ 503.16

Total 2 raw suppliers

Chemical Property of Ethyl 3-amino-3-(3-fluorophenyl)propanoate hydrochloride

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:247.0775346
Heavy Atom Count:16
Complexity:211

Purity/Quality:

98% ^*data from raw suppliers

ETHYL 3-AMINO-3-(3-FLUOROPHENYL)PROPANOATE HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)CC(C1=CC(=CC=C1)F)N.Cl

Technology Process of Ethyl 3-amino-3-(3-fluorophenyl)propanoate hydrochloride

There total 2 articles about Ethyl 3-amino-3-(3-fluorophenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 64-17-5
ethanol

: 117391-51-2,723284-81-9
(+/-)-3-amino-3-(3-fluorophenyl)propanoic acid

: 182199-73-1
ethyl (+/-)-3-amino-3-(3-fluorophenyl)propanoate hydrochloride

Guidance literature:: With thionyl chloride; at -15 ℃; Reflux; Inert atmosphere;
DOI:10.1021/ml5002079

Reference yield:

: 456-48-4
3-Fluorobenzaldehyde

: 182199-73-1
ethyl (+/-)-3-amino-3-(3-fluorophenyl)propanoate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / isopropyl alcohol / Reflux

2: thionyl chloride / -15 °C / Reflux; Inert atmosphere

With thionyl chloride; ammonium acetate; In isopropyl alcohol;
DOI:10.1021/ml5002079

Reference yield: 19.0%

: 182199-73-1
ethyl (+/-)-3-amino-3-(3-fluorophenyl)propanoate hydrochloride

: 478055-40-2
5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoic acid

: (RS)-ethyl 3-(3-fluorophenyl)-3-(5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanamido)propanoate

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ml5002079