(R)-1-(2-(bromomethyl)-1,3-dioxolan-2-yl)-N-(1-phenylethyl)cyclopropanecarboxamide

Base Information

Chemical Name:(R)-1-(2-(bromomethyl)-1,3-dioxolan-2-yl)-N-(1-phenylethyl)cyclopropanecarboxamide
CAS No.:129321-58-0
Molecular Formula:C₁₆H₂₀BrNO₃
Molecular Weight:354.244
Hs Code.:
DSSTox Substance ID:DTXSID501130580

Synonyms:SCHEMBL769302;WSWSBCGRIYIPSA-GFCCVEGCSA-N;DTXSID501130580;(R)-1-(2-(bromomethyl)-1,3-dioxolan-2-yl)-N-(1-phenylethyl)cyclopropanecarboxamide;1-[2-(Bromomethyl)-1,3-dioxolan-2-yl]-N-[(1R)-1-phenylethyl]cyclopropanecarboxamide;129321-58-0

Suppliers and Price of (R)-1-(2-(bromomethyl)-1,3-dioxolan-2-yl)-N-(1-phenylethyl)cyclopropanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-(2-(bromomethyl)-1,3-dioxolan-2-yl)-N-(1-phenylethyl)cyclopropanecarboxamide

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:353.06266
Heavy Atom Count:21
Complexity:385

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC=CC=C1)NC(=O)C2(CC2)C3(OCCO3)CBr
Isomeric SMILES:C[C@H](C1=CC=CC=C1)NC(=O)C2(CC2)C3(OCCO3)CBr

Technology Process of (R)-1-(2-(bromomethyl)-1,3-dioxolan-2-yl)-N-(1-phenylethyl)cyclopropanecarboxamide

There total 4 articles about (R)-1-(2-(bromomethyl)-1,3-dioxolan-2-yl)-N-(1-phenylethyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129321-57-9
(R)-N-(1-phenylethyl)-1-<1,1-(ethylenedioxy)ethyl>-1-cyclopropanecarboxamide

: 129321-58-0
(R)-N-(1-phenylethyl)-1-<2-bromo-1,1-(ethylenedioxy)ethyl>-1-cyclopropanecarboxamide

Guidance literature:: With bromine; In 1,4-dioxane; dichloromethane; for 2h;
DOI:10.1021/jm00046a019

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 129321-58-0
(R)-N-(1-phenylethyl)-1-<2-bromo-1,1-(ethylenedioxy)ethyl>-1-cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) ethyl chloroformate, triethylamine / 1.) -30 deg C, 40 min, 2.) -20 deg C, 1.5 h

2: 227.8 g / p-toluenesulfonic acid monohydrate / benzene / 24 h / Heating

3: 326.0 g / bromine / dioxane; CH₂Cl₂ / 2 h

With bromine; chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; dichloromethane; benzene;
DOI:10.1021/jm00046a019

Reference yield:

: 56172-71-5
1-Acetylcyclopropane-1-carboxylic acid

: 129321-58-0
(R)-N-(1-phenylethyl)-1-<2-bromo-1,1-(ethylenedioxy)ethyl>-1-cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) ethyl chloroformate, triethylamine / 1.) -30 deg C, 40 min, 2.) -20 deg C, 1.5 h

2: 227.8 g / p-toluenesulfonic acid monohydrate / benzene / 24 h / Heating

3: 326.0 g / bromine / dioxane; CH₂Cl₂ / 2 h

With bromine; chloroformic acid ethyl ester; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; dichloromethane; benzene;
DOI:10.1021/jm00046a019