1,1-dimethylethyl (2R)-2-[(1R)-1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-oxobutyl]-4-morpholinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl (2R)-2-[(1R)-1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-oxobutyl]-4-morpholinecarboxylate
CAS No.:1070871-71-4
Molecular Formula:C₂₇H₃₄FNO₅
Molecular Weight:471.569
Hs Code.:

Synonyms:1,1-dimethylethyl (2R)-2-[(1R)-1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-oxobutyl]-4-morpholinecarboxylate

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Chemical Property of 1,1-dimethylethyl (2R)-2-[(1R)-1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-oxobutyl]-4-morpholinecarboxylate

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Technology Process of 1,1-dimethylethyl (2R)-2-[(1R)-1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-oxobutyl]-4-morpholinecarboxylate

There total 7 articles about 1,1-dimethylethyl (2R)-2-[(1R)-1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-oxobutyl]-4-morpholinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070870-44-8
1,1-dimethylethyl (2R)-2-[(1R)-1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4,4-bis(methyloxy)butyl]-4-morpholinecarboxylate

: 1,1-dimethylethyl (2R)-2-[(2R)-2-(3'-ethyl-6-fluoro-2-biphenylyl)-5-hydroxytetrahydro-2-furanyl]-4-morpholinecarboxylate

: 1070871-71-4
1,1-dimethylethyl (2R)-2-[(1R)-1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-oxobutyl]-4-morpholinecarboxylate

Guidance literature:: 1,1-dimethylethyl (2R)-2-[(1R)-1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4,4-bis(methyloxy)butyl]-4-morpholinecarboxylate; With water; pyridinium p-toluenesulfonate; In acetone; at 100 ℃; for 0.5h; Microwave irradiation;

With sodium hydrogencarbonate; In acetone;

Reference yield:

: 135065-70-2
(2R)-2-[(benzyloxy)methyl]morpholine

: 1,1-dimethylethyl (2R)-2-[(2R)-2-(3'-ethyl-6-fluoro-2-biphenylyl)-5-hydroxytetrahydro-2-furanyl]-4-morpholinecarboxylate

: 1070871-71-4
1,1-dimethylethyl (2R)-2-[(1R)-1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-oxobutyl]-4-morpholinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / water; acetone / 0 - 20 °C

2.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; sodium hydrogencarbonate; sodium bromide / water; acetone / 0 - 20 °C

4.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

5.1: magnesium; ethylene dibromide / tetrahydrofuran / 1 h / Reflux

5.2: -30 - 20 °C

6.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

6.2: -78 - 20 °C

7.1: water / pyridinium p-toluenesulfonate / acetone / 0.5 h / 100 °C / microwave irradiation

With n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; magnesium; ethylene dibromide; N-ethyl-N,N-diisopropylamine; sodium bromide; palladium on activated charcoal; pyridinium p-toluenesulfonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 135097-68-6
tert-butyl (2R)-2-[(benzyloxy)methyl]morpholine-4-carboxylate

: 1,1-dimethylethyl (2R)-2-[(2R)-2-(3'-ethyl-6-fluoro-2-biphenylyl)-5-hydroxytetrahydro-2-furanyl]-4-morpholinecarboxylate

: 1070871-71-4
1,1-dimethylethyl (2R)-2-[(1R)-1-(3'-ethyl-6-fluoro-2-biphenylyl)-1-hydroxy-4-oxobutyl]-4-morpholinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C

2.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; sodium hydrogencarbonate; sodium bromide / water; acetone / 0 - 20 °C

3.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

4.1: magnesium; ethylene dibromide / tetrahydrofuran / 1 h / Reflux

4.2: -30 - 20 °C

5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

5.2: -78 - 20 °C

6.1: water / pyridinium p-toluenesulfonate / acetone / 0.5 h / 100 °C / microwave irradiation

With n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; water; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; magnesium; ethylene dibromide; N-ethyl-N,N-diisopropylamine; sodium bromide; palladium on activated charcoal; pyridinium p-toluenesulfonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetone;