(S)-1-N-benzyloxycarbonylamino-1-(4-carboxymethyl-5-methyl-2-oxazolyl)-2-phenylethane

Base Information

Chemical Name:(S)-1-N-benzyloxycarbonylamino-1-(4-carboxymethyl-5-methyl-2-oxazolyl)-2-phenylethane
CAS No.:208665-33-2
Molecular Formula:C₂₂H₂₂N₂O₅
Molecular Weight:394.427
Hs Code.:

Synonyms:(S)-1-N-benzyloxycarbonylamino-1-(4-carboxymethyl-5-methyl-2-oxazolyl)-2-phenylethane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-N-benzyloxycarbonylamino-1-(4-carboxymethyl-5-methyl-2-oxazolyl)-2-phenylethane

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Technology Process of (S)-1-N-benzyloxycarbonylamino-1-(4-carboxymethyl-5-methyl-2-oxazolyl)-2-phenylethane

There total 5 articles about (S)-1-N-benzyloxycarbonylamino-1-(4-carboxymethyl-5-methyl-2-oxazolyl)-2-phenylethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 208665-37-6
2-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-3-oxo-butyric acid methyl ester

: 208665-33-2
(S)-1-N-benzyloxycarbonylamino-1-(4-carboxymethyl-5-methyl-2-oxazolyl)-2-phenylethane

Guidance literature:: With iodine; triethylamine; triphenylphosphine; In dichloromethane; Ambient temperature;
DOI:10.1016/S0957-4166(98)00109-8

Reference yield:

: 24762-04-7
2-Diazo-3-oxo-butyric acid methyl ester

: 208665-33-2
(S)-1-N-benzyloxycarbonylamino-1-(4-carboxymethyl-5-methyl-2-oxazolyl)-2-phenylethane

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / Rh₂(OAc)4 / CHCl₃ / 24 h / Heating

2: 84 percent / PPh₃, I₂, Et₃N / CH₂Cl₂ / Ambient temperature

With dirhodium tetraacetate; iodine; triethylamine; triphenylphosphine; In dichloromethane; chloroform;
DOI:10.1016/S0957-4166(98)00109-8

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 208665-33-2
(S)-1-N-benzyloxycarbonylamino-1-(4-carboxymethyl-5-methyl-2-oxazolyl)-2-phenylethane

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methylmorpholine / CH₂Cl₂ / 0.33 h / -15 °C

2: NH₃ / CH₂Cl₂ / 12 h / Ambient temperature

3: 92 percent / Rh₂(OAc)4 / CHCl₃ / 24 h / Heating

4: 84 percent / PPh₃, I₂, Et₃N / CH₂Cl₂ / Ambient temperature

With 4-methyl-morpholine; dirhodium tetraacetate; ammonia; iodine; triethylamine; triphenylphosphine; In dichloromethane; chloroform;
DOI:10.1016/S0957-4166(98)00109-8