2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate

Base Information

Chemical Name:2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate
CAS No.:908337-63-3
Molecular Formula:C₂₁H₁₆Cl₃F₂NO₆
Molecular Weight:522.717
Hs Code.:

2<SUP>1</SUP>-deoxy-2<SUP>1</SUP>,2<SUP>1</SUP>-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate

Synonyms:2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate

Suppliers and Price of 2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate

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Technology Process of 2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate

There total 1 articles about 2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1173824-58-2,143157-25-9,143157-22-6
(2R,3R)-2-((benzoyloxy)methyl)-4,4-difluoro-5-hydroxyoxolan-3-yl benzoate

: 545-06-2
trichloroacetonitrile

: 908337-63-3
2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at -10 - 20 ℃; for 5h;

Reference yield: 51.7%

: 908337-63-3
2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate

: 51-21-8
5-fluorouracil

: 908339-71-9
2¹-deoxy-2¹,2¹-difluoro-3,5-di-O-benzoyl-5-fluorouridine

Guidance literature:: 5-fluorouracil; With 1,1,1,3,3,3-hexamethyl-disilazane; methanesulfonic acid; In acetonitrile; at 110 - 120 ℃; for 5 - 6h;

2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 90 ℃; for 10h;

With water; In dichloromethane; acetonitrile;

Reference yield: 37.0%

: 908337-63-3
2¹-deoxy-2¹,2¹-difluoro-3,5-bis-O-benzoyl-D-ribose trichloroacetimidate

: 54230-57-8
N⁴-acetyl-O-trimethylsilylcytosine

: (2R,3R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4,4-difluorotetrahydrofuran-3-yl benzoate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; Product distribution / selectivity; Heating / reflux;