ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE

Base Information

• Chemical Name: ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE
• CAS No.: 76629-17-9
• Molecular Formula: C₇H₁₀N₂O₂S*ClH
• Molecular Weight: 222.696
• Hs Code.: 2934100090
• Mol file: 76629-17-9.mol

Synonyms:4-Thiazoleaceticacid, 2-amino-, ethyl ester, monohydrochloride (9CI)

Chemical Property of ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE

Chemical Property:

• PSA: 93.45000
• LogP: 2.21410

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-(2-Amino-1,3-thiazol-4-yl)acetateHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate Hydrochloride is a reagent used in the preparation of antitrypnosomal and penicillin derivatives.

Technology Process of ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE

There total 2 articles about ETHYL 2-(2-AMINO-1,3-THIAZOL-4-YL)ACETATE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethanol (64-17-5) + 2-(2-aminothiazol-4-yl)acetic acid hydrochloride (66659-20-9) → Ethyl (2-aminothiazol-4-yl)acetate hydrochloride (76629-17-9)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/0223-5234(93)90125-X

Reference yield: 79.0%

ethyl (2-chloroaceto)acetate (638-07-3) + thiourea (17356-08-0) → Ethyl (2-aminothiazol-4-yl)acetate hydrochloride (76629-17-9)

Guidance literature:

1.) EtOH, steam-bath, 2.) room temperature, 16 h;

Reference yield:

Ethyl (2-aminothiazol-4-yl)acetate hydrochloride (76629-17-9) + 2-Benzyloxycarbonylamino-5-ethoxycarbonyloxy-5-oxo-pentanoic acid methyl ester → ethyl acetate (150716-16-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; Yield given; Ambient temperature;

DOI:10.1016/0223-5234(93)90125-X

upstream raw materials:

ethanol

2-(2-aminothiazol-4-yl)acetic acid hydrochloride

ethyl (2-chloroaceto)acetate

thiourea

Downstream raw materials:

ethyl acetate

[2-(2,4-Dioxo-imidazolidin-1-yl)-thiazol-4-yl]-acetic acid ethyl ester

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