1-{3-[(3-Chloro-propyl)-(4-fluoro-phenyl)-methyl-silanyl]-propyl}-1H-[1,2,4]triazole

Base Information

Chemical Name:1-{3-[(3-Chloro-propyl)-(4-fluoro-phenyl)-methyl-silanyl]-propyl}-1H-[1,2,4]triazole
CAS No.:191926-85-9
Molecular Formula:C₁₅H₂₁ClFN₃Si
Molecular Weight:325.889
Hs Code.:

Synonyms:1-{3-[(3-Chloro-propyl)-(4-fluoro-phenyl)-methyl-silanyl]-propyl}-1H-[1,2,4]triazole

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Chemical Property of 1-{3-[(3-Chloro-propyl)-(4-fluoro-phenyl)-methyl-silanyl]-propyl}-1H-[1,2,4]triazole

Chemical Property:

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Technology Process of 1-{3-[(3-Chloro-propyl)-(4-fluoro-phenyl)-methyl-silanyl]-propyl}-1H-[1,2,4]triazole

There total 4 articles about 1-{3-[(3-Chloro-propyl)-(4-fluoro-phenyl)-methyl-silanyl]-propyl}-1H-[1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 191926-84-8
3-[(4-Fluoro-phenyl)-methyl-(3-[1,2,4]triazol-1-yl-propyl)-silanyl]-propan-1-ol

: 191926-85-9
1-{3-[(3-Chloro-propyl)-(4-fluoro-phenyl)-methyl-silanyl]-propyl}-1H-[1,2,4]triazole

Guidance literature:: With pyridine; thionyl chloride; In chloroform; at 25 ℃; Heating; 1.) 0 deg C;
DOI:10.1002/hlca.19970800308

Reference yield:

: 352-13-6
4-flourophenylmagnesium bromide

: 191926-85-9
1-{3-[(3-Chloro-propyl)-(4-fluoro-phenyl)-methyl-silanyl]-propyl}-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether; tetrahydrofuran / 8 h / Heating

2: 31 percent / diethyl ether; tetrahydrofuran / 20 h / Heating

3: 79 percent / NaI / dimethylformamide / 20 h / Heating

4: 80 percent / 1.) pyridine, thionyl chloride / CHCl₃ / 25 °C / Heating; 1.) 0 deg C

With pyridine; thionyl chloride; sodium iodide; In tetrahydrofuran; diethyl ether; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800308

Reference yield:

: Chloro-(3-chloro-propyl)-(4-fluoro-phenyl)-methyl-silane

: 191926-85-9
1-{3-[(3-Chloro-propyl)-(4-fluoro-phenyl)-methyl-silanyl]-propyl}-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 3 steps

1: 31 percent / diethyl ether; tetrahydrofuran / 20 h / Heating

2: 79 percent / NaI / dimethylformamide / 20 h / Heating

3: 80 percent / 1.) pyridine, thionyl chloride / CHCl₃ / 25 °C / Heating; 1.) 0 deg C

With pyridine; thionyl chloride; sodium iodide; In tetrahydrofuran; diethyl ether; chloroform; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800308