N-Phenyl-alpha,alpha-difluorobenzeneacetamide

Base Information

Chemical Name:N-Phenyl-alpha,alpha-difluorobenzeneacetamide
CAS No.:339-30-0
Molecular Formula:C₁₄H₁₁F₂NO
Molecular Weight:247.244
Hs Code.:
DSSTox Substance ID:DTXSID201287336
Nikkaji Number:J2.998.583I

Synonyms:N-Phenyl-alpha,alpha-difluorobenzeneacetamide;KHKBYDFFRPLOSX-UHFFFAOYSA-N;DTXSID201287336;339-30-0;alpha,alpha-Difluoro-N-phenylbenzeneacetamide

Suppliers and Price of N-Phenyl-alpha,alpha-difluorobenzeneacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Phenyl-alpha,alpha-difluorobenzeneacetamide

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:247.08087030
Heavy Atom Count:18
Complexity:282

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(C(=O)NC2=CC=CC=C2)(F)F

Technology Process of N-Phenyl-alpha,alpha-difluorobenzeneacetamide

There total 14 articles about N-Phenyl-alpha,alpha-difluorobenzeneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 127427-45-6
2-bromo-2,2-difluoro-N-phenyl-acetamide

: 98-80-6
phenylboronic acid

: 339-30-0
2,2-difluoro-N-2-diphenylacetamide

Guidance literature:: With [2,2]bipyridinyl; nickel(II) nitrate hexahydrate; potassium carbonate; In 1,4-dioxane; at 80 ℃; for 24h; Schlenk technique; Inert atmosphere;
DOI:10.1002/anie.201405653

Reference yield: 82.0%

: 62-53-3
aniline

: 103-80-0
phenylacetyl chloride

: 339-30-0
2,2-difluoro-N-2-diphenylacetamide

Guidance literature:: phenylacetyl chloride; With pyridine; tin(II) trifluoromethanesulfonate; Selectfluor; potassium tetrakis(pentafluorophenyl)borate; In acetonitrile; at 20 ℃; for 3h; Inert atmosphere;

aniline; In acetonitrile; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol2019295

Reference yield: 79.0%

: 127427-45-6
2-bromo-2,2-difluoro-N-phenyl-acetamide

: 71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1
benzene

: 339-30-0
2,2-difluoro-N-2-diphenylacetamide

Guidance literature:: With tris[2-phenylpyridinato-C₂,N]iridium(III); potassium acetate; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere; Schlenk technique; Irradiation;
DOI:10.1021/ol502676y