Technology Process of 5-(4-nitrophenyl)-2-{1-(pyrimidin-2-yl)-1H-indol-2-yl}oxazole
There total 2 articles about 5-(4-nitrophenyl)-2-{1-(pyrimidin-2-yl)-1H-indol-2-yl}oxazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper diacetate; acetic acid; 1-Methylnaphthalene;
In
o-xylene;
at 150 ℃;
for 4h;
Inert atmosphere;
DOI:10.1002/anie.201201491
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride; N,N-dimethyl-formamide / mineral oil / 0.5 h / 20 °C / Inert atmosphere
1.2: 12 h / 150 °C / Inert atmosphere
2.1: copper diacetate; acetic acid; 1-Methylnaphthalene / o-xylene / 4 h / 150 °C / Inert atmosphere
With
copper diacetate; sodium hydride; acetic acid; 1-Methylnaphthalene; N,N-dimethyl-formamide;
In
o-xylene; mineral oil;
DOI:10.1002/anie.201201491