2,3-dimethyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one

Base Information

Chemical Name:2,3-dimethyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one
CAS No.:1473452-77-5
Molecular Formula:C₂₂H₂₀N₂O₄
Molecular Weight:376.412
Hs Code.:

Synonyms:2,3-dimethyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one

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Chemical Property of 2,3-dimethyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one

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Technology Process of 2,3-dimethyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one

There total 4 articles about 2,3-dimethyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1473452-74-2
3-methyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one

: 74-88-4
methyl iodide

: 1473452-77-5
2,3-dimethyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one

Guidance literature:: 3-methyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1473452-73-1
1-(2-fluoro-5-nitrophenyl)-3-methyl-6,7-dihydro-2H-isoindol-4(5H)-one

: 1473452-77-5
2,3-dimethyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

2.2: 2 h / 20 °C

With sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1473452-17-3
1-bromo-3-methyl-6,7-dihydro-2H-isoindol-4(5H)-one

: 1473452-77-5
2,3-dimethyl-1-(5-nitro-2-phenoxyphenyl)-6,7-dihydro-2H-isoindol-4(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 6.5 h / 60 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 50 °C

3.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

3.2: 2 h / 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; caesium carbonate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;