1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:212574-95-3
Molecular Formula:C₃₈H₄₃N₂O₈PS
Molecular Weight:718.808
Hs Code.:

1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Synonyms:1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

There total 5 articles about 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 198637-74-0
2-chloro-“spiro”-4,4-pentamethylene-1,3,2-oxathiaphospholane

: 212574-95-3
1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 0.0833333h; Ambient temperature;
DOI:10.1021/ja973801j

Reference yield:

: 52958-74-4
1-[(2-formylcyclohexyl)disulfanyl]cyclohexanecarbaldehyde

: 212574-95-3
1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / NaBH₄ / propan-2-ol

2: 70 percent / LiAlH₄ / diethyl ether

3: 76 percent / PCl₃, pyridine / benzene

4: iPr₂NEt / acetonitrile / 0.08 h / Ambient temperature

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; phosphorus trichloride; In diethyl ether; isopropyl alcohol; acetonitrile; benzene;
DOI:10.1080/07328319808004710

Reference yield:

: 212574-87-3
[1-(1-Hydroxymethyl-cyclohexyldisulfanyl)-cyclohexyl]-methanol

: 212574-95-3
1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(3-oxa-1-thia-2-phospha-spiro[4.5]dec-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / LiAlH₄ / diethyl ether

2: 76 percent / PCl₃, pyridine / benzene

3: iPr₂NEt / acetonitrile / 0.08 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; N-ethyl-N,N-diisopropylamine; phosphorus trichloride; In diethyl ether; acetonitrile; benzene;
DOI:10.1080/07328319808004710