[(2-{3-benzoyl-7-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy}-ethyl)-tert-butoxycarbonylmethyl-amino]-acetic acid tert-butyl ester

Base Information

Chemical Name:[(2-{3-benzoyl-7-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy}-ethyl)-tert-butoxycarbonylmethyl-amino]-acetic acid tert-butyl ester
CAS No.:349458-80-6
Molecular Formula:C₄₄H₆₀N₂O₁₃
Molecular Weight:824.966
Hs Code.:

[(2-{3-benzoyl-7-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy}-ethyl)-tert-butoxycarbonylmethyl-amino]-acetic acid tert-butyl ester

Synonyms:[(2-{3-benzoyl-7-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy}-ethyl)-tert-butoxycarbonylmethyl-amino]-acetic acid tert-butyl ester

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Chemical Property of [(2-{3-benzoyl-7-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy}-ethyl)-tert-butoxycarbonylmethyl-amino]-acetic acid tert-butyl ester

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Technology Process of [(2-{3-benzoyl-7-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy}-ethyl)-tert-butoxycarbonylmethyl-amino]-acetic acid tert-butyl ester

There total 8 articles about [(2-{3-benzoyl-7-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy}-ethyl)-tert-butoxycarbonylmethyl-amino]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 85916-13-8
tert-butyl iminodiacetate

: 349458-76-0
methanesulfonic acid 2-[3-benzoyl-7-(2-methanesulfonyloxy-ethoxy)-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy]-ethyl ester

: 349458-80-6
[(2-{3-benzoyl-7-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy}-ethyl)-tert-butoxycarbonylmethyl-amino]-acetic acid tert-butyl ester

Guidance literature:: With sodium carbonate; sodium iodide; In acetonitrile; at 120 ℃; for 96h;
DOI:10.1016/S0040-4020(01)00168-5

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 349458-80-6
[(2-{3-benzoyl-7-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy}-ethyl)-tert-butoxycarbonylmethyl-amino]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / piperidine / ethanol / 4 h / Heating

2: 78 percent / triethylamine / CH₂Cl₂ / 0.33 h

3: 43 percent / sodium iodide; sodium carbonate / acetonitrile / 96 h / 120 °C

With piperidine; sodium carbonate; triethylamine; sodium iodide; In ethanol; dichloromethane; acetonitrile; 1: Claisen condensation;
DOI:10.1016/S0040-4020(01)00168-5

Reference yield:

: 119309-58-9
(2-ethoxycarbonylmethoxy-5-formyl-phenoxy)-acetic acid ethyl ester

: 349458-80-6
[(2-{3-benzoyl-7-[2-(bis-tert-butoxycarbonylmethyl-amino)-ethoxy]-2-oxo-4a,8a-dihydro-2H-chromen-6-yloxy}-ethyl)-tert-butoxycarbonylmethyl-amino]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 71 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 20 °C

2.1: LiAlH₄ / tetrahydrofuran / 3 h

2.2: 88 percent / sodium hydroxide / tetrahydrofuran / 4 h / Heating

3.1: trifluoroacetic acid / 3 h / 90 °C

3.2: 55 percent / trifluoroacetic acid / H₂O / 4 h / Heating

4.1: 83 percent / piperidine / ethanol / 4 h / Heating

5.1: 78 percent / triethylamine / CH₂Cl₂ / 0.33 h

6.1: 43 percent / sodium iodide; sodium carbonate / acetonitrile / 96 h / 120 °C

With piperidine; lithium aluminium tetrahydride; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; 1.1: Baeyer-Villiger rearrangement / 4.1: Claisen condensation;
DOI:10.1016/S0040-4020(01)00168-5