4-bromo-N-β,β-trimethylphenylalanyl-N¹-[(1S,2E)-4-ethoxy-1-isopropyl-3-methyl-4-oxo-2-butenyl]-N¹,3-dimethyl-valinamide

Base Information

• Chemical Name: 4-bromo-N-β,β-trimethylphenylalanyl-N¹-[(1S,2E)-4-ethoxy-1-isopropyl-3-methyl-4-oxo-2-butenyl]-N¹,3-dimethyl-valinamide
• CAS No.: 676627-57-9
• Molecular Formula: C₂₉H₄₆BrN₃O₄
• Molecular Weight: 580.606

Synonyms:4-bromo-N-β,β-trimethylphenylalanyl-N¹-[(1S,2E)-4-ethoxy-1-isopropyl-3-methyl-4-oxo-2-butenyl]-N¹,3-dimethyl-valinamide

Chemical Property of 4-bromo-N-β,β-trimethylphenylalanyl-N¹-[(1S,2E)-4-ethoxy-1-isopropyl-3-methyl-4-oxo-2-butenyl]-N¹,3-dimethyl-valinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-N-β,β-trimethylphenylalanyl-N¹-[(1S,2E)-4-ethoxy-1-isopropyl-3-methyl-4-oxo-2-butenyl]-N¹,3-dimethyl-valinamide

There total 5 articles about 4-bromo-N-β,β-trimethylphenylalanyl-N¹-[(1S,2E)-4-ethoxy-1-isopropyl-3-methyl-4-oxo-2-butenyl]-N¹,3-dimethyl-valinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-N,β,β-trimethylphenylalanine (676627-55-7) + ethyl (S,E)-4-((S)-2-amino-N,3,3-trimethylbutanamide)-2,5-dimethylhexa-2-enoate hydrochloride (610786-70-4) → 4-bromo-N-β,β-trimethylphenylalanyl-N1-[(1S,2E)-4-ethoxy-1-isopropyl-3-methyl-4-oxo-2-butenyl]-N1,3-dimethyl-valinamide (676627-57-9)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 21h;

DOI:10.1021/ja048619e

Reference yield:

2-oxo-3-(phenyl)propionic acid (156-06-9) → 4-bromo-N-β,β-trimethylphenylalanyl-N1-[(1S,2E)-4-ethoxy-1-isopropyl-3-methyl-4-oxo-2-butenyl]-N1,3-dimethyl-valinamide (676627-57-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: aq. NaOH / tetrahydrofuran

1.2: tetrahydrofuran / 5 h / Heating

2.1: aq. NaOH / tetrahydrofuran

2.2: tetrahydrofuran / 20 °C

3.1: 79 percent / bromine; iron / CCl₄ / Heating

4.1: tetrahydrofuran / 1 h / 20 °C

4.2: 49 percent / BH₃*pyridine / tetrahydrofuran / Heating

5.1: benzotriazol-1-yloxytrispyrrolodinophosphonium*PF₆; diisopropylethylamine / CH₂Cl₂ / 21 h / 20 °C

With sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; iron; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane;

DOI:10.1021/ja048619e

Reference yield:

α-keto-β-phenylbutyric acid (4658-69-9) → 4-bromo-N-β,β-trimethylphenylalanyl-N1-[(1S,2E)-4-ethoxy-1-isopropyl-3-methyl-4-oxo-2-butenyl]-N1,3-dimethyl-valinamide (676627-57-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: aq. NaOH / tetrahydrofuran

1.2: tetrahydrofuran / 20 °C

2.1: 79 percent / bromine; iron / CCl₄ / Heating

3.1: tetrahydrofuran / 1 h / 20 °C

3.2: 49 percent / BH₃*pyridine / tetrahydrofuran / Heating

4.1: benzotriazol-1-yloxytrispyrrolodinophosphonium*PF₆; diisopropylethylamine / CH₂Cl₂ / 21 h / 20 °C

With sodium hydroxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; iron; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane;

DOI:10.1021/ja048619e

upstream raw materials:

4-bromo-N,β,β-trimethylphenylalanine

ethyl (S,E)-4-((S)-2-amino-N,3,3-trimethylbutanamide)-2,5-dimethylhexa-2-enoate hydrochloride

2-oxo-3-(phenyl)propionic acid

α-keto-β-phenylbutyric acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 676627-57-9 4-bromo-N-β,β-trimethylphenylalanyl-N¹-[(1S,2E)-4-ethoxy-1-isopropyl-3-methyl-4-oxo-2-butenyl]-N¹,3-dimethyl-valinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send