[5-methyl-4-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-3-isoxazolyl]methanol

Base Information

Chemical Name:[5-methyl-4-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-3-isoxazolyl]methanol
CAS No.:1257875-23-2
Molecular Formula:C₁₇H₁₃F₃N₂O₃
Molecular Weight:350.297
Hs Code.:

Synonyms:[5-methyl-4-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-3-isoxazolyl]methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [5-methyl-4-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-3-isoxazolyl]methanol

Chemical Property:

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Technology Process of [5-methyl-4-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-3-isoxazolyl]methanol

There total 1 articles about [5-methyl-4-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-3-isoxazolyl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 854015-61-5
(4-iodo-5-methylisoxazol-3-yl)methanol

: 1257875-27-6
(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)boronic acid

: 1257875-23-2
[5-methyl-4-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-3-isoxazolyl]methanol

Guidance literature:: With sodium carbonate; palladium 10% on activated carbon; In ethanol; water; toluene; at 85 ℃; for 4.5h; Inert atmosphere;

Reference yield:

: 1257875-23-2
[5-methyl-4-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-3-isoxazolyl]methanol

: 78191-00-1
N-Methoxy-N-methylacetamide

: 2-(hydroxymethyl)-6-methyl-6'-{4-[(trifluoromethyl)oxy]phenyl}-3,3'-bipyridin-4(1H)-one

Guidance literature:: [5-methyl-4-(6-{4-[(trifluoromethyl)oxy]phenyl}-3-pyridinyl)-3-isoxazolyl]methanol; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

N-Methoxy-N-methylacetamide; In tetrahydrofuran; hexane; at -78 ℃; for 2.75h; Inert atmosphere;

With hydrogen; palladium 10% on activated carbon; In ethanol; under 1500.15 Torr; Product distribution / selectivity; Inert atmosphere;