5(S)-(isoxazol-3-yl-aminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one

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Chemical Name:5(S)-(isoxazol-3-yl-aminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one
CAS No.:1443005-71-7
Molecular Formula:C₁₇H₁₉F₂N₅O₄
Molecular Weight:395.366
Hs Code.:

Synonyms:5(S)-(isoxazol-3-yl-aminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one

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Chemical Property of 5(S)-(isoxazol-3-yl-aminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one

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Technology Process of 5(S)-(isoxazol-3-yl-aminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one

There total 6 articles about 5(S)-(isoxazol-3-yl-aminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1443005-68-2
5(R)-(isoxazol-3-yl-N-(tert-butoxycarbonyl)aminomethyl)-3-(3,5-difluoro-4-(2-(tert-butoxycarbonyl)[1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one

: 1443005-71-7
5(S)-(isoxazol-3-yl-aminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h; under 760.051 Torr;
DOI:10.1016/j.ejmech.2013.03.003

Reference yield:

: 66684-58-0
3,4,5-trifluoronitrobenzene

: 1443005-71-7
5(S)-(isoxazol-3-yl-aminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / Reflux

2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

3.1: sodium carbonate / methanol / 0.5 h

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

4.2: 23.17 h / -78 - 20 °C / Inert atmosphere

5.1: tributylphosphine / tetrahydrofuran / 21 h / 20 °C

6.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr

With n-butyllithium; tributylphosphine; palladium 10% on activated carbon; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; hexane; acetonitrile;
DOI:10.1016/j.ejmech.2013.03.003

Reference yield:

: 952151-41-6
5-(2,6-difluoro-4-nitrophenyl)[1,2,5]oxadiazepane-2-carboxylic acid tert-butyl ester

: 1443005-71-7
5(S)-(isoxazol-3-yl-aminomethyl)-3-(3,5-difluoro-4-([1,2,5]oxadiazepan-5-yl)phenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

2.1: sodium carbonate / methanol / 0.5 h

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

3.2: 23.17 h / -78 - 20 °C / Inert atmosphere

4.1: tributylphosphine / tetrahydrofuran / 21 h / 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / 760.05 Torr

With n-butyllithium; tributylphosphine; palladium 10% on activated carbon; hydrogen; sodium carbonate; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/j.ejmech.2013.03.003