C₂₂H₄₀O₃Si

Base Information

Chemical Name:C₂₂H₄₀O₃Si
CAS No.:1312136-48-3
Molecular Formula:C₂₂H₄₀O₃Si
Molecular Weight:380.643
Hs Code.:

C<sub>22</sub>H<sub>40</sub>O<sub>3</sub>Si

Synonyms:C₂₂H₄₀O₃Si

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Chemical Property of C₂₂H₄₀O₃Si

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Technology Process of C₂₂H₄₀O₃Si

There total 15 articles about C₂₂H₄₀O₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1312136-11-0
(R)-4-benzyl-3-((2R,4R,6R)-7-(benzyloxy)-2,6-dimethyl-4-(tert-butyldimethylsilyloxy)heptanoyl)oxazolidin-2-one

: 1312136-48-3
C₂₂H₄₀O₃Si

Guidance literature:: (R)-4-benzyl-3-((2R,4R,6R)-7-(benzyloxy)-2,6-dimethyl-4-(tert-butyldimethylsilyloxy)heptanoyl)oxazolidin-2-one; With lithium borohydride; In tetrahydrofuran; methanol; water; at 0 - 20 ℃; for 1h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; methanol; water; at 0 ℃; Inert atmosphere;
DOI:10.3390/molecules16075422

Reference yield:

: 1312136-34-7
(R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one

: 1312136-48-3
C₂₂H₄₀O₃Si

Guidance literature:: Multi-step reaction with 12 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -40 °C / Inert atmosphere

1.2: 4 h / -20 °C / Inert atmosphere

2.1: lithium borohydride / tetrahydrofuran; methanol; water / 2.5 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4.1: water; toluene-4-sulfonic acid / N,N-dimethyl-formamide / 3 h / 0 - 30 °C / 80 Torr

5.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

6.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

7.1: diisobutylaluminium hydride / hexane; dichloromethane / 1 h / -78 °C / Inert atmosphere

7.2: Inert atmosphere

8.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 20 °C / Inert atmosphere

10.1: Rh/Al₂O₃; hydrogen / ethyl acetate / 2 h / 20 °C

11.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

11.2: 0.5 h / -20 °C / Inert atmosphere

12.1: lithium borohydride / tetrahydrofuran; methanol; water / 1 h / 0 - 20 °C / Inert atmosphere

12.2: 0 °C / Inert atmosphere

With pyridine; 1H-imidazole; lithium borohydride; Rh/Al₂O₃; water; hydrogen; sulfur trioxide pyridine complex; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1.1: Evans asymmetric alkylation / 8.1: Parikh-Doering oxidation / 9.1: Horner-Wadsworth-Emmons olefination / 11.1: Evans asymmetric alkylation;
DOI:10.3390/molecules16075422

Reference yield:

: (R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2-propenoic acid methyl ester

: 1312136-48-3
C₂₂H₄₀O₃Si

Guidance literature:: Multi-step reaction with 15 steps

1.1: hydrogen / ethanol / 20 °C

2.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 0 °C / Inert atmosphere

2.2: pH 4 / Inert atmosphere

3.1: pivaloyl chloride; triethylamine / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -40 °C / Inert atmosphere

4.2: 4 h / -20 °C / Inert atmosphere

5.1: lithium borohydride / tetrahydrofuran; methanol; water / 2.5 h / 0 - 20 °C / Inert atmosphere

5.2: 0 °C / Inert atmosphere

6.1: tetra-(n-butyl)ammonium iodide; sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

7.1: water; toluene-4-sulfonic acid / N,N-dimethyl-formamide / 3 h / 0 - 30 °C / 80 Torr

8.1: pyridine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

9.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

10.1: diisobutylaluminium hydride / hexane; dichloromethane / 1 h / -78 °C / Inert atmosphere

10.2: Inert atmosphere

11.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

12.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 20 °C / Inert atmosphere

13.1: Rh/Al₂O₃; hydrogen / ethyl acetate / 2 h / 20 °C

14.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

14.2: 0.5 h / -20 °C / Inert atmosphere

15.1: lithium borohydride / tetrahydrofuran; methanol; water / 1 h / 0 - 20 °C / Inert atmosphere

15.2: 0 °C / Inert atmosphere

With pyridine; 1H-imidazole; lithium borohydride; Rh/Al₂O₃; water; hydrogen; sulfur trioxide pyridine complex; pivaloyl chloride; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 4.1: Evans asymmetric alkylation / 11.1: Parikh-Doering oxidation / 12.1: Horner-Wadsworth-Emmons olefination / 14.1: Evans asymmetric alkylation;
DOI:10.3390/molecules16075422