Carbamic acid, (2-hydroxy-1-methylpropyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (2-hydroxy-1-methylpropyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 752135-63-0
• Molecular Formula: C₉H₁₉NO₃
• Molecular Weight: 189.255
• Hs Code.: 2924297099
• Mol file: 752135-63-0.mol

Synonyms:(2-Hydroxy-1-methylpropyl)carbamicacid tert-butyl ester

Chemical Property of Carbamic acid, (2-hydroxy-1-methylpropyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Boiling Point: 286.5±23.0 °C(Predicted)
• PKA: 12.41±0.46(Predicted)
• PSA: 58.56000
• Density: 1.008±0.06 g/cm3(Predicted)
• LogP: 1.67130

Purity/Quality:

97% ^*data from raw suppliers

3-(Boc-amino)-2-butanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (2-hydroxy-1-methylpropyl)-, 1,1-dimethylethyl ester (9CI)

There total 5 articles about Carbamic acid, (2-hydroxy-1-methylpropyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(+/-)-tert-butyl (3-oxobutan-2-yl)carbamate → (+/-)-tert-butyl (3-hydroxybutan-2-yl)carbamate (752135-63-0)

Guidance literature:

With methanol; sodium tetrahydroborate; at 25 ℃; for 0.5h;

Reference yield: 14.0%

3-aminobutan-2-ol (42551-55-3) + di-tert-butyl dicarbonate (24424-99-5) → (+/-)-tert-butyl (3-hydroxybutan-2-yl)carbamate (752135-63-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

3-nitrobutan-2-ol (6270-16-2) + di-tert-butyl dicarbonate (24424-99-5) → (+/-)-tert-butyl (3-hydroxybutan-2-yl)carbamate (752135-63-0)

Guidance literature:

3-nitrobutan-2-ol; With palladium 10% on activated carbon; hydrogen; In methanol; at 10 - 35 ℃; for 2h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 0 ℃; for 3h;

upstream raw materials:

3-aminobutan-2-ol

di-tert-butyl dicarbonate

(+/-)-tert-butyl (1-(methoxy(methyl)amino)-1-oxopropan-2-yl)carbamate

N-t-butyloxycarbonyl-DL-alanine

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