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42551-55-3

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42551-55-3 Usage

General Description

(2S,3R)-3-aminobutan-2-ol, also known as L-threo-3-aminobutan-2-ol, is a chemical compound with the molecular formula C4H10NO. It is an amino alcohol that contains an amine group and a hydroxyl group in its structure. (2S,3R)-3-aminobutan-2-ol is a chiral molecule, meaning it has two enantiomers, (2S,3R) and (2R,3S), with the (2S,3R) form being the naturally occurring isomer. (2S,3R)-3-aminobutan-2-ol is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It can also be used as a chiral auxiliary in asymmetric synthesis and as a ligand in coordination chemistry. Additionally, this compound has potential applications in the field of drug development and medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 42551-55-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,5,5 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 42551-55:
(7*4)+(6*2)+(5*5)+(4*5)+(3*1)+(2*5)+(1*5)=103
103 % 10 = 3
So 42551-55-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H11NO/c1-3(5)4(2)6/h3-4,6H,5H2,1-2H3/t3-,4+/m1/s1

42551-55-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-aminobutan-2-ol

1.2 Other means of identification

Product number -
Other names 2-amino-2-methyl-i-propanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:42551-55-3 SDS

42551-55-3Relevant articles and documents

Rapid and Quantitative Profiling of Substrate Specificity of ω-Transaminases for Ketones

Han, Sang-Woo,Shin, Jong-Shik

, p. 3287 - 3295 (2019/06/21)

ω-Transaminases (ω-TAs) have gained growing attention owing to their capability for asymmetric synthesis of chiral amines from ketones. Reliable high-throughput activity assay of ω-TAs is essential in carrying out extensive substrate profiling and establishing a robust screening platform. Here we report spectrophotometric and colorimetric methods enabling rapid quantitation of ω-TA activities toward ketones in a 96-well microplate format. The assay methods employ benzylamine, a reactive amino donor for ω-TAs, as a cosubstrate and exploit aldehyde dehydrogenase (ALDH) as a reporter enzyme, leading to formation of benzaldehyde detectable by ALDH owing to concomitant NADH generation. Spectrophotometric substrate profiling of two wild-type ω-TAs of opposite stereoselectivity was carried out at 340 nm with 22 ketones, revealing subtle differences in substrate specificities that were consistent with docking simulation results obtained with cognate amines. Colorimetric readout for naked eye detection of the ω-TA activity was also demonstrated by supplementing the assay mixture with color-developing reagents whose color reaction could be quantified at 580 nm. The colorimetric assay was applied to substrate profiling of an engineered ω-TA for 24 ketones, leading to rapid identification of reactive ketones. The ALDH-based assay is expected to be promising for high-throughput screening of enzyme collections and mutant libraries to fish out the best ω-TA candidate as well as to tailor enzyme properties for efficient amination of a target ketone.

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