(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-4-methylpentanamide

Base Information

Chemical Name:(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-4-methylpentanamide
CAS No.:1374968-57-6
Molecular Formula:C₁₇H₂₁N₅OS
Molecular Weight:343.453
Hs Code.:

Synonyms:(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-4-methylpentanamide

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Chemical Property of (R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-4-methylpentanamide

Chemical Property:

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Technology Process of (R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-4-methylpentanamide

There total 3 articles about (R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374968-56-5
(R)-2-(3-bromo-4-cyanophenylamino)-4-methylpentanamide

: 71134-43-5,52547-00-9
3-methyl-5-aminoisothiazole hydrochloride

: 1374968-57-6
(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-4-methylpentanamide

Guidance literature:: With potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 120 ℃; for 18h; Inert atmosphere;

Reference yield:

: 36282-26-5
2-bromo-4-fluorobenzonitrile

: 1374968-57-6
(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 100 °C

2: potassium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 18 h / 120 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; dimethyl sulfoxide;

Reference yield:

: 80970-09-8
(R)-2-amino-4-methylpentanamide hydrochloride

: 1374968-57-6
(R)-2-(4-cyano-3-(3-methylisothiazol-5-ylamino)phenylamino)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 100 °C

2: potassium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 18 h / 120 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; dimethyl sulfoxide;