Multi-step reaction with 8 steps
1: thionyl chloride / 4.17 h / 0 °C / Reflux
2: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / chloroform / 15 h / 0 - 20 °C
3: methanol; lithium hydroxide / tetrahydrofuran / 4 h / 65 °C
4: N-ethyl-N,N-diisopropylamine; HATU; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 15 h / 0 - 20 °C
5: tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid / dichloromethane; ethyl acetate / 3 h / 20 °C
6: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 0.5 h
7: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C
8: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 20 °C
With
methanol; tetrakis(triphenylphosphine) palladium(0); thionyl chloride; 1-hydroxy-7-aza-benzotriazole; 1,3-dimethylbarbituric acid; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; lithium hydroxide; 1,1'-azodicarbonyl-dipiperidine;
In
tetrahydrofuran; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;