rac-1,1-bis(ethylthio)-3-hydroxy-3-(4methoxyphenyl)propan-2-one

Base Information

• Chemical Name: rac-1,1-bis(ethylthio)-3-hydroxy-3-(4methoxyphenyl)propan-2-one
• CAS No.: 130718-84-2
• Molecular Formula: C₁₄H₂₀O₃S₂
• Molecular Weight: 300.443
• Mol file: 130718-84-2.mol

Synonyms:rac-1,1-bis(ethylthio)-3-hydroxy-3-(4methoxyphenyl)propan-2-one

Chemical Property of rac-1,1-bis(ethylthio)-3-hydroxy-3-(4methoxyphenyl)propan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of rac-1,1-bis(ethylthio)-3-hydroxy-3-(4methoxyphenyl)propan-2-one

There total 3 articles about rac-1,1-bis(ethylthio)-3-hydroxy-3-(4methoxyphenyl)propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,1-bis(ethylthio)-3-(4-methoxyphenyl)-3-(trimethylsilyloxy)propan-2-one (130718-81-9) → rac-1,1-bis(ethylthio)-3-hydroxy-3-(4methoxyphenyl)propan-2-one (130718-84-2)

Guidance literature:

With hydrogenchloride; for 18h; Ambient temperature;

Reference yield:

methyl 2-hydroxy-2-(4-methoxyphenyl)acetate (13305-14-1) → rac-1,1-bis(ethylthio)-3-hydroxy-3-(4methoxyphenyl)propan-2-one (130718-84-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / imidazole, 4-(dimethylamino)pyridine / diethyl ether / Ambient temperature

2: 1.) LDA / 1.) hexane, THF, -78 deg C, 30 min, 2.) -78 deg C, 30 min

3: 95 percent / 1 M hydrochloric acid / 18 h / Ambient temperature

With 1H-imidazole; hydrogenchloride; dmap; lithium diisopropyl amide; In diethyl ether;

Reference yield:

methyl 2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate (130796-19-9,55000-34-5) → rac-1,1-bis(ethylthio)-3-hydroxy-3-(4methoxyphenyl)propan-2-one (130718-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA / 1.) hexane, THF, -78 deg C, 30 min, 2.) -78 deg C, 30 min

2: 95 percent / 1 M hydrochloric acid / 18 h / Ambient temperature

With hydrogenchloride; lithium diisopropyl amide;

upstream raw materials:

1,1-bis(ethylthio)-3-(4-methoxyphenyl)-3-(trimethylsilyloxy)propan-2-one

methyl 2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

methyl 2-hydroxy-2-(4-methoxyphenyl)acetate

Downstream raw materials:

erythro rac-1,1-bis(ethylthio)-3-(4-methoxyphenyl)propane-2,3-diol

cis-4--2,2-dimethyl-5-(4-methoxyphenyl)-1,3-dioxolan

cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carbaldehyde

cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid