Benzeneacetic acid, 4-methoxy-alpha-[(trimethylsilyl)oxy]-, methyl ester

Base Information

Chemical Name:Benzeneacetic acid, 4-methoxy-alpha-[(trimethylsilyl)oxy]-, methyl ester
CAS No.:130796-19-9
Molecular Formula:C₁₃H₂₀O₄Si
Molecular Weight:268.385
Hs Code.:
DSSTox Substance ID:DTXSID401207796
Nikkaji Number:J109.155G

Synonyms:Methyl 4-methoxymandelate, TMS derivative;Benzeneacetic acid, 4-methoxy-.alpha.-[(trimethylsilyl)oxy]-, methyl ester;DTXSID401207796;Methyl ester, trimethylsilyl ether of p-Methoxymandelic acid;Methyl (4-methoxyphenyl)[(trimethylsilyl)oxy]acetate #;Methyl 4-methoxy-alpha-[(trimethylsilyl)oxy]benzeneacetate;4-Methoxy-alpha-(trimethylsiloxy)benzeneacetic acid methyl ester;130796-19-9;55000-34-5

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzeneacetic acid, 4-methoxy-alpha-[(trimethylsilyl)oxy]-, methyl ester

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:268.11308565
Heavy Atom Count:18
Complexity:267

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(C(=O)OC)O[Si](C)(C)C

Technology Process of Benzeneacetic acid, 4-methoxy-alpha-[(trimethylsilyl)oxy]-, methyl ester

There total 1 articles about Benzeneacetic acid, 4-methoxy-alpha-[(trimethylsilyl)oxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 75-77-4
chloro-trimethyl-silane

: 13305-14-1
methyl 2-hydroxy-2-(4-methoxyphenyl)acetate

: 130796-19-9,55000-34-5
methyl 2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

Guidance literature:: With 1H-imidazole; dmap; In diethyl ether; Ambient temperature;

Reference yield:

: 130796-19-9,55000-34-5
methyl 2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

: 106146-94-5,113289-70-6,114055-17-3,122517-80-0,122517-81-1,125073-64-5,130796-41-7
methyl 2,3-dihydroxy-3-(4-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LDA / 1.) hexane, THF, -78 deg C, 30 min, 2.) -78 deg C, 30 min

2: 95 percent / 1 M hydrochloric acid / 18 h / Ambient temperature

3: 100 percent / NaBH₄ / ethanol / 0.67 h / Ambient temperature

4: 88 percent / 4-toluenesulfonic acid / Ambient temperature

5: 94 percent / yellow mercuric oxide, BF₃*Et₂O / tetrahydrofuran; H₂O / 1 h / Ambient temperature

6: 75 percent / silver oxide / Ambient temperature

7: 98 percent / diethyl ether / 0.17 h / 0 °C

8: 87 percent / p-toluenesulfonic acid, methanol / 20 h

With hydrogenchloride; methanol; sodium tetrahydroborate; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; mercury(II) oxide; silver(l) oxide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; water;

Reference yield:

: 130796-19-9,55000-34-5
methyl 2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetate

: 122431-48-5,130796-38-2,130796-39-3
methyl cis-5-(4-methoxyphenyl)-2,2-dimethyl-1,3-dioxolan-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LDA / 1.) hexane, THF, -78 deg C, 30 min, 2.) -78 deg C, 30 min

2: 95 percent / 1 M hydrochloric acid / 18 h / Ambient temperature

3: 100 percent / NaBH₄ / ethanol / 0.67 h / Ambient temperature

4: 88 percent / 4-toluenesulfonic acid / Ambient temperature

5: 94 percent / yellow mercuric oxide, BF₃*Et₂O / tetrahydrofuran; H₂O / 1 h / Ambient temperature

6: 75 percent / silver oxide / Ambient temperature

7: 98 percent / diethyl ether / 0.17 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; mercury(II) oxide; silver(l) oxide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; water;