2S-[2R,3R-bisbenzyloxy-3R-methyl-5R-(triisopropyl-silanyloxy)-tetrahydropyran-4-yloxy]-4S-{3-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanoxy)-tetrahydropyran-2R-yl]-2S-methyloxiranyl}butyric acid methyl ester

Base Information

Chemical Name:2S-[2R,3R-bisbenzyloxy-3R-methyl-5R-(triisopropyl-silanyloxy)-tetrahydropyran-4-yloxy]-4S-{3-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanoxy)-tetrahydropyran-2R-yl]-2S-methyloxiranyl}butyric acid methyl ester
CAS No.:569661-05-8
Molecular Formula:C₅₈H₉₆O₁₄Si₂
Molecular Weight:1073.56
Hs Code.:

2S-[2R,3R-bisbenzyloxy-3R-methyl-5R-(triisopropyl-silanyloxy)-tetrahydropyran-4-yloxy]-4S-{3-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanoxy)-tetrahydropyran-2R-yl]-2S-methyloxiranyl}butyric acid methyl ester

Synonyms:2S-[2R,3R-bisbenzyloxy-3R-methyl-5R-(triisopropyl-silanyloxy)-tetrahydropyran-4-yloxy]-4S-{3-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanoxy)-tetrahydropyran-2R-yl]-2S-methyloxiranyl}butyric acid methyl ester

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Chemical Property of 2S-[2R,3R-bisbenzyloxy-3R-methyl-5R-(triisopropyl-silanyloxy)-tetrahydropyran-4-yloxy]-4S-{3-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanoxy)-tetrahydropyran-2R-yl]-2S-methyloxiranyl}butyric acid methyl ester

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Technology Process of 2S-[2R,3R-bisbenzyloxy-3R-methyl-5R-(triisopropyl-silanyloxy)-tetrahydropyran-4-yloxy]-4S-{3-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanoxy)-tetrahydropyran-2R-yl]-2S-methyloxiranyl}butyric acid methyl ester

There total 5 articles about 2S-[2R,3R-bisbenzyloxy-3R-methyl-5R-(triisopropyl-silanyloxy)-tetrahydropyran-4-yloxy]-4S-{3-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanoxy)-tetrahydropyran-2R-yl]-2S-methyloxiranyl}butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 569661-05-8
2S-[2R,3R-bisbenzyloxy-3R-methyl-5R-(triisopropyl-silanyloxy)-tetrahydropyran-4-yloxy]-4S-{3-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanoxy)-tetrahydropyran-2R-yl]-2S-methyloxiranyl}butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 2,6-lutidine / various solvent(s) / 0.25 h / -78 °C

2: CH₂Cl₂; methanol / 25 h / -30 °C

With 2,6-dimethylpyridine; In methanol; dichloromethane;
DOI:10.1021/ja029225v

Reference yield:

: 569661-02-5
7R,8R-dibenzyloxy-2S-{5-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanyloxy)-tetrahydropyran-2R-yl]-3-methylpent-3E-enyl}-8R-methyltetrahydropyrano[3R,4R-b][1,4]dioxin-3-one

: 569661-05-8
2S-[2R,3R-bisbenzyloxy-3R-methyl-5R-(triisopropyl-silanyloxy)-tetrahydropyran-4-yloxy]-4S-{3-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanoxy)-tetrahydropyran-2R-yl]-2S-methyloxiranyl}butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: aq. lithium hydroxide / tetrahydrofuran / 0.33 h / 0 °C

2: 2.57 g / 2,6-lutidine; N-iodosuccinimide / CH₂Cl₂ / 3.5 h / 0 - 20 °C

3: 92 percent / 2,6-lutidine / various solvent(s) / 0.25 h / -78 °C

4: CH₂Cl₂; methanol / 25 h / -30 °C

With 2,6-dimethylpyridine; lithium hydroxide; N-iodo-succinimide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ja029225v

Reference yield:

: 569661-65-0
2S-(2R,3R-bis-benzyloxy-5R-hydroxy-3R-methyl-tetrahydro-pyran-4R-yloxy)-7-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanyloxoy)-tetrahydropyran-2R-yl]-5-methylhept-5E-enoic acid

: 569661-05-8
2S-[2R,3R-bisbenzyloxy-3R-methyl-5R-(triisopropyl-silanyloxy)-tetrahydropyran-4-yloxy]-4S-{3-[6R-(2,2-dimethyl-[1,3]dioxan-5-ylmethyl)-4S-methoxymethoxy-3R-(triethylsilanoxy)-tetrahydropyran-2R-yl]-2S-methyloxiranyl}butyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2.57 g / 2,6-lutidine; N-iodosuccinimide / CH₂Cl₂ / 3.5 h / 0 - 20 °C

2: 92 percent / 2,6-lutidine / various solvent(s) / 0.25 h / -78 °C

3: CH₂Cl₂; methanol / 25 h / -30 °C

With 2,6-dimethylpyridine; N-iodo-succinimide; In methanol; dichloromethane;
DOI:10.1021/ja029225v