3-benzenesulfonyl-7-methoxymethoxy-8-methylene-9-oxo-1-(9-phenyl-9H-fluoren-9-yl)-1a,2,3,8,9,9a-hexahydro-1H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-5-carboxylic acid methyl ester

Base Information

Chemical Name:3-benzenesulfonyl-7-methoxymethoxy-8-methylene-9-oxo-1-(9-phenyl-9H-fluoren-9-yl)-1a,2,3,8,9,9a-hexahydro-1H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-5-carboxylic acid methyl ester
CAS No.:488097-13-8
Molecular Formula:C₄₁H₃₄N₂O₇S
Molecular Weight:698.796
Hs Code.:

3-benzenesulfonyl-7-methoxymethoxy-8-methylene-9-oxo-1-(9-phenyl-9<i>H</i>-fluoren-9-yl)-1a,2,3,8,9,9a-hexahydro-1<i>H</i>-1,3-diaza-benzo[<i>a</i>]cyclopropa[<i>e</i>]cyclooctene-5-carboxylic acid methyl ester

Synonyms:3-benzenesulfonyl-7-methoxymethoxy-8-methylene-9-oxo-1-(9-phenyl-9H-fluoren-9-yl)-1a,2,3,8,9,9a-hexahydro-1H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-5-carboxylic acid methyl ester

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Chemical Property of 3-benzenesulfonyl-7-methoxymethoxy-8-methylene-9-oxo-1-(9-phenyl-9H-fluoren-9-yl)-1a,2,3,8,9,9a-hexahydro-1H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-5-carboxylic acid methyl ester

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Technology Process of 3-benzenesulfonyl-7-methoxymethoxy-8-methylene-9-oxo-1-(9-phenyl-9H-fluoren-9-yl)-1a,2,3,8,9,9a-hexahydro-1H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-5-carboxylic acid methyl ester

There total 8 articles about 3-benzenesulfonyl-7-methoxymethoxy-8-methylene-9-oxo-1-(9-phenyl-9H-fluoren-9-yl)-1a,2,3,8,9,9a-hexahydro-1H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 488097-10-5
methyl (3S,4S)-1-benzenesulfonyl-7-methoxymethoxy-5-oxo-(3,4)-[N-(9-phenylfluoren-9-yl)aziridino]-1,2,3,4,5,6-hexahydrobenzo[1,2-b]azocin-9-carboxylate

: 488097-13-8
3-benzenesulfonyl-7-methoxymethoxy-8-methylene-9-oxo-1-(9-phenyl-9H-fluoren-9-yl)-1a,2,3,8,9,9a-hexahydro-1H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-5-carboxylic acid methyl ester

Guidance literature:: With N-benzyl-trimethylammonium hydroxide; at 65 ℃; for 1h;
DOI:10.1021/jo0206521

Reference yield:

: 26158-00-9,5928-72-3
benzene-sulfonic acid monohydrate

: 488097-13-8
3-benzenesulfonyl-7-methoxymethoxy-8-methylene-9-oxo-1-(9-phenyl-9H-fluoren-9-yl)-1a,2,3,8,9,9a-hexahydro-1H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / thionyl chloride / benzene / 3 h / Heating

2: 76 percent / pyridine / 14 h / 65 °C

3: 72 percent / KHMDS / tetrahydrofuran / 2 h / -20 - 3 °C

4: 97 percent / Triton B / 1 h / 65 °C

With pyridine; thionyl chloride; N-benzyl-trimethylammonium hydroxide; potassium hexamethylsilazane; In tetrahydrofuran; benzene;
DOI:10.1021/jo0206521

Reference yield:

: methyl (3S)-3-[N-[3-[N-(benzyloxycarbonyl)amino]-2-hydroxy-4-methoxy-4-oxobutyl]amino]-5-methoxymethoxy-4-methylbenzoate

: 488097-13-8
3-benzenesulfonyl-7-methoxymethoxy-8-methylene-9-oxo-1-(9-phenyl-9H-fluoren-9-yl)-1a,2,3,8,9,9a-hexahydro-1H-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: H₂ / 10percent Pd/C / methanol / 20 °C

2.1: K₃PO₄; Pb(NO₃)2 / acetonitrile / 36 h / 20 °C

2.2: 16.26 g / hydrochloric acid / methanol; H₂O / 1 h / Heating

3.1: 76 percent / pyridine / 14 h / 65 °C

4.1: 72 percent / KHMDS / tetrahydrofuran / 2 h / -20 - 3 °C

5.1: 97 percent / Triton B / 1 h / 65 °C

With pyridine; potassium phosphate; lead(II) nitrate; hydrogen; N-benzyl-trimethylammonium hydroxide; potassium hexamethylsilazane; 10percent Pd/C; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jo0206521