2-amino-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetonitrile

Base Information

• Chemical Name: 2-amino-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetonitrile
• CAS No.: 115787-63-8
• Molecular Formula: C₁₃H₁₁N₅O₃
• Molecular Weight: 285.262
• Mol file: 115787-63-8.mol

Synonyms:2-amino-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetonitrile

Chemical Property of 2-amino-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetonitrile

There total 1 articles about 2-amino-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetic acid ethyl ester (115787-62-7) → 2-amino-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetonitrile (115787-63-8)

Guidance literature:

With sodium hydroxide; for 1h; Ambient temperature;

DOI:10.1021/jm00087a015

Reference yield: 71.0%

2-amino-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetonitrile (115787-63-8) → 2-Amino-3,5-dihydro-7-(phenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one (132138-67-1)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; for 1h; under 2585.7 Torr;

DOI:10.1016/0040-4039(96)01242-7

Reference yield:

2-amino-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetonitrile (115787-63-8) → 9-benzyl-9-deazaguanine (115787-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / ethanol / Ambient temperature

2: 6 N HCl

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/0040-4039(96)01242-7

upstream raw materials:

2-amino-α-cyano-1,6-dihydro-5-nitro-6-oxo-α-(phenylmethyl)-4-pyrimidineacetic acid ethyl ester

Downstream raw materials:

9-benzyl-9-deazaguanine

2-Amino-3,5-dihydro-7-(phenylmethyl)-4H-pyrrolo[3,2-d]pyrimidin-4-one