N'-<1-(4-N-benzyl-N-methylamino-2,6-difluorophenyl)-2-propyl>-N,N-dibenzylglycinamide

Base Information

• Chemical Name: N'-<1-(4-N-benzyl-N-methylamino-2,6-difluorophenyl)-2-propyl>-N,N-dibenzylglycinamide
• CAS No.: 226410-98-6
• Molecular Formula: C₃₃H₃₅F₂N₃O
• Molecular Weight: 527.657
• Mol file: 226410-98-6.mol

Synonyms:N'-<1-(4-N-benzyl-N-methylamino-2,6-difluorophenyl)-2-propyl>-N,N-dibenzylglycinamide

Chemical Property of N'-<1-(4-N-benzyl-N-methylamino-2,6-difluorophenyl)-2-propyl>-N,N-dibenzylglycinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-<1-(4-N-benzyl-N-methylamino-2,6-difluorophenyl)-2-propyl>-N,N-dibenzylglycinamide

There total 11 articles about N'-<1-(4-N-benzyl-N-methylamino-2,6-difluorophenyl)-2-propyl>-N,N-dibenzylglycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-{2-[4-(benzyl-methyl-amino)-2,6-difluoro-phenyl]-1-methyl-ethyl}-2-chloro-acetamide + dibenzylamine (103-49-1) → N'-<1-(4-N-benzyl-N-methylamino-2,6-difluorophenyl)-2-propyl>-N,N-dibenzylglycinamide (226410-98-6)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 100 ℃; for 5h; Yield given;

DOI:10.1016/S0223-5234(99)80047-6

Reference yield:

3,5-difluorobenzoic acid (455-40-3) → N'-<1-(4-N-benzyl-N-methylamino-2,6-difluorophenyl)-2-propyl>-N,N-dibenzylglycinamide (226410-98-6)

Guidance literature:

Multi-step reaction with 10 steps

1: SOCl₂, DMF / CH₂Cl₂ / 4 h / Heating

2: conc. NH₄OH / tetrahydrofuran / 0 °C

3: 1) Br₂, aq. NaOH / 1) reflux, 2 h, 2) reflux, 2 h

4: LiAlH₄ / diethyl ether / 3.5 h / Heating

5: K₂CO₃, KI / dimethylformamide / 100 °C

6: 88 percent / 1.6 M nBuLi / tetrahydrofuran; hexane / 1.5 h / -80 °C

7: NH₄OAc / ethanol / 5 h / Heating

8: LiAlH₄ / tetrahydrofuran; diethyl ether / 2 h / Heating

9: aq. NaOH / toluene / 1 h / 0 °C

10: K₂CO₃, KI / dimethylformamide / 5 h / 100 °C

With ammonium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; ammonium acetate; bromine; potassium carbonate; N,N-dimethyl-formamide; potassium iodide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0223-5234(99)80047-6

Reference yield:

3,5-difluoroaniline (372-39-4) → N'-<1-(4-N-benzyl-N-methylamino-2,6-difluorophenyl)-2-propyl>-N,N-dibenzylglycinamide (226410-98-6)

Guidance literature:

Multi-step reaction with 8 steps

1: 82 percent / 2 h / Heating

2: LiAlH₄ / diethyl ether / 3.5 h / Heating

3: K₂CO₃, KI / dimethylformamide / 100 °C

4: 88 percent / 1.6 M nBuLi / tetrahydrofuran; hexane / 1.5 h / -80 °C

5: NH₄OAc / ethanol / 5 h / Heating

6: LiAlH₄ / tetrahydrofuran; diethyl ether / 2 h / Heating

7: aq. NaOH / toluene / 1 h / 0 °C

8: K₂CO₃, KI / dimethylformamide / 5 h / 100 °C

With sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; ammonium acetate; potassium carbonate; potassium iodide; In tetrahydrofuran; diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0223-5234(99)80047-6

upstream raw materials:

dibenzylamine

3,5-difluorobenzoic acid

3,5-difluoroaniline

3,5-difluorobenzamide