(-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

Base Information

• Chemical Name: (-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone
• CAS No.: 220416-64-8
• Molecular Formula: C₂₉H₄₁NO₃
• Molecular Weight: 451.649
• Mol file: 220416-64-8.mol

Synonyms:(-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

Chemical Property of (-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

There total 1 articles about (-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S,5R)-3,3-dichloro-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone → (-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone (220416-64-8)

Guidance literature:

With zinc copper; ammonium chloride; In methanol; at 20 ℃; for 1h;

DOI:10.1021/jo981908z

Reference yield: 98.0%

benzyl chloroformate (501-53-1,94274-21-2) + (-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone (220416-64-8) → (-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone (220416-70-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1h;

DOI:10.1021/jo981908z

Reference yield:

(-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone (220416-64-8) → (2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine (130120-89-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

2: 166 mg / lithium triethylborohydride / tetrahydrofuran / 0.5 h / -78 °C

3: 103 mg / triethylsilane; boron trifluoride diethyl etherate / CH₂Cl₂ / 3 h / -78 °C

4: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With triethylsilane; n-butyllithium; boron trifluoride diethyl etherate; lithium triethylborohydride; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; 1: Acylation / 2: Reduction / 3: Reduction / 4: deprotection;

DOI:10.1021/jo981908z

Downstream raw materials:

(-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

(2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine