(-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

Base Information

• Chemical Name: (-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone
• CAS No.: 220416-70-6
• Molecular Formula: C₃₇H₄₇NO₅
• Molecular Weight: 585.784

Synonyms:(-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

Chemical Property of (-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

There total 2 articles about (-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl chloroformate (501-53-1,94274-21-2) + (-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone (220416-64-8) → (-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone (220416-70-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1h;

DOI:10.1021/jo981908z

Reference yield:

(4S,5R)-3,3-dichloro-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone → (-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone (220416-70-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.54 g / ammonium chloride; zinc-copper / methanol / 1 h / 20 °C

2: 98 percent / n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

With n-butyllithium; zinc copper; ammonium chloride; In tetrahydrofuran; methanol; hexane; 1: Dehalogenation / 2: Acylation;

DOI:10.1021/jo981908z

Reference yield:

(-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone (220416-70-6) → (2R,3R)-5-Hydroxy-2-(4-methoxy-benzyl)-3-[(S)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:

With lithium triethylborohydride; In tetrahydrofuran; at -78 ℃; for 0.5h;

DOI:10.1021/jo981908z

upstream raw materials:

benzyl chloroformate

(-)-(4R,5R)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

Downstream raw materials:

(2R,3R)-1-(Benzyloxycarbonyl)-2-<(4-methoxyphenyl)-methyl>-3-hydroxypyrrolidine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 220416-70-6 (-)-(4R,5R)-1-(benzyloxycarbonyl)-5-(4-methoxybenzyl)-4-((1S)-1-(2,4,6-triisopropylphenyl)ethoxy)-2-pyrrolidinone

Send

Send

Metric Ton KG G Pound L ML

Send

Send