Technology Process of C13H15Br2NO2
There total 1 articles about C13H15Br2NO2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,6-dibromoaniline;
With
trimethylaluminum;
In
dichloromethane; toluene;
at 0 - 20 ℃;
for 0.5h;
Inert atmosphere;
α-(1-methylethylidene)-γ-butyrolactone;
In
dichloromethane; toluene;
at 20 ℃;
for 72h;
Inert atmosphere;
DOI:10.1021/ja405548b
- Guidance literature:
-
With
1H-imidazole;
In
dichloromethane;
at 0 - 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/ja405548b
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
2.1: palladium diacetate; triphenylphosphine; triethylamine / toluene; water / 24 h / 20 °C / Reflux; Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere
3.2: 4 h / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
5.1: triethylamine; dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 3.5 h / -78 - 20 °C / Inert atmosphere
6.1: tetrahydrofuran / 4 h / 20 °C / Cooling; Inert atmosphere
7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere
With
1H-imidazole; oxalyl dichloride; tetrabutyl ammonium fluoride; palladium diacetate; sodium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;
2.1: |Heck Reaction;
DOI:10.1021/ja405548b
