1-methyl-N-(4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazol-5-yl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:1-methyl-N-(4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazol-5-yl)-1H-pyrazole-5-carboxamide
CAS No.:1318756-85-2
Molecular Formula:C₁₉H₁₉F₃N₄OS
Molecular Weight:408.447
Hs Code.:

Synonyms:1-methyl-N-(4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazol-5-yl)-1H-pyrazole-5-carboxamide

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Chemical Property of 1-methyl-N-(4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazol-5-yl)-1H-pyrazole-5-carboxamide

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Technology Process of 1-methyl-N-(4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazol-5-yl)-1H-pyrazole-5-carboxamide

There total 3 articles about 1-methyl-N-(4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazol-5-yl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 16034-46-1
1-methyl-1H-pyrazole-5-carboxylic acid

: 1318758-05-2
tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate

: 1318756-85-2
1-methyl-N-(4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazol-5-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate; With hydrogenchloride; In ethanol; water; at 50 ℃; for 1.5h;

With sodium hydrogencarbonate; sodium hydroxide; In ethanol; water; at 20 ℃; pH=10 - 11;

1-methyl-1H-pyrazole-5-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl acetamide; at 60 ℃; for 1.5h;

Reference yield:

: 1318758-03-0
ethyl 4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazole-5-carboxylate

: 1318756-85-2
1-methyl-N-(4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazol-5-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / methanol / 3 h / 20 °C

2.1: triethylamine; diphenyl phosphoryl azide / 4 h / 90 °C

3.1: hydrogenchloride / ethanol; water / 1.5 h / 50 °C

3.2: 20 °C / pH 10 - 11

3.3: 1.5 h / 60 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; triethylamine; sodium hydroxide; In methanol; ethanol; water;

Reference yield:

: 1318758-04-1
4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazole-5-carboxylic acid

: 1318756-85-2
1-methyl-N-(4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazol-5-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; diphenyl phosphoryl azide / 4 h / 90 °C

2.1: hydrogenchloride / ethanol; water / 1.5 h / 50 °C

2.2: 20 °C / pH 10 - 11

2.3: 1.5 h / 60 °C

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In ethanol; water;