tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate

Base Information

Chemical Name:tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate
CAS No.:1318758-05-2
Molecular Formula:C₁₉H₂₃F₃N₂O₂S
Molecular Weight:400.465
Hs Code.:

Synonyms:tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate

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Chemical Property of tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate

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Technology Process of tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate

There total 2 articles about tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1318758-04-1
4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazole-5-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1318758-05-2
tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; at 90 ℃; for 4h;

Reference yield:

: 1318758-03-0
ethyl 4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazole-5-carboxylate

: 1318758-05-2
tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol / 3 h / 20 °C

2: triethylamine; diphenyl phosphoryl azide / 4 h / 90 °C

With diphenyl phosphoryl azide; water; triethylamine; sodium hydroxide; In methanol;

Reference yield: 47.0%

: 16034-46-1
1-methyl-1H-pyrazole-5-carboxylic acid

: 1318758-05-2
tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate

: 1318756-85-2
1-methyl-N-(4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl}-1,3-thiazol-5-yl)-1H-pyrazole-5-carboxamide

Guidance literature:: tert-butyl (4-methyl-2-{1-methyl-1-[3-(trifluoromethyl)phenyl]ethyl]-1,3-thiazol-5-yl)carbamate; With hydrogenchloride; In ethanol; water; at 50 ℃; for 1.5h;

With sodium hydrogencarbonate; sodium hydroxide; In ethanol; water; at 20 ℃; pH=10 - 11;

1-methyl-1H-pyrazole-5-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl acetamide; at 60 ℃; for 1.5h;