ethyl 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate

Base Information

Chemical Name:ethyl 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate
CAS No.:1237717-15-5
Molecular Formula:C₁₇H₁₉F₃N₂O₃
Molecular Weight:356.345
Hs Code.:

Synonyms:ethyl 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate

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Chemical Property of ethyl 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate

Chemical Property:

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Technology Process of ethyl 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate

There total 2 articles about ethyl 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1237714-73-6
ethyl 4-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate

: 75-31-0
isopropylamine

: 1237717-15-5
ethyl 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 5 ℃;

Reference yield:

: 854015-40-0
4-methyl-5-(4-trifluoromethyl phenyl)-isoxazole-3-carboxylic acid ethyl ester

: 1237717-15-5
ethyl 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane

2: sodium hydrogencarbonate / tetrahydrofuran

With N-Bromosuccinimide; sodium hydrogencarbonate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane;
DOI:10.1016/j.bmcl.2011.01.051

Reference yield:

: 1237717-15-5
ethyl 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate

: 1237717-16-6
4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid

Guidance literature:: ethyl 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; for 2h;

With hydrogenchloride; In water;