854015-40-0

Basic information

• Product Name: 3-Isoxazolecarboxylic acid, 4-methyl-5-[4-(trifluoromethyl)phenyl]-, ethyl ester
• CAS NO: 854015-40-0
• Molecular Formula: C14H12F3NO3
• Molecular Weight: 299.249
• Mol File: 854015-40-0.mol

Chemical Properties

• CAS DataBase Reference: 3-Isoxazolecarboxylic acid, 4-methyl-5-[4-(trifluoromethyl)phenyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isoxazolecarboxylic acid, 4-methyl-5-[4-(trifluoromethyl)phenyl]-, ethyl ester(854015-40-0)
• EPA Substance Registry System: 3-Isoxazolecarboxylic acid, 4-methyl-5-[4-(trifluoromethyl)phenyl]-, ethyl ester(854015-40-0)

Safety Data

• Hazardous Substances Data: 854015-40-0(Hazardous Substances Data)

Upstream product

• 854015-42-2 ethyl 5-bromo-4-methyl-1,2-oxazole-3-carboxylate 
• 128796-39-4 4-trifluoromethylphenylboronic acid 

Downstream Products

• 1237717-23-5 (R)-4-((isopropylamino)methyl)-N-(3-methylbutan-2-yl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1237717-19-9 N-cyclopentyl-4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)-phenyl)isoxazole-3-carboxamide 
• 1237717-17-7 (S)-4-((isopropylamino)methyl)-N-(3-methylbutan-2-yl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1237717-16-6 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid 
• 1237717-15-5 ethyl 4-((isopropylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate 
• 1237715-25-1 N-((1R,3S)-3-hydroxycyclohexyl)-4-((isopropylamino)methyl)-5-(4-(trifluoro-methyl)phenyl)isoxazole-3-carboxamide 
• 1237714-78-1 4-(hydroxymethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid 
• 1237717-59-7 ethyl 4-(hydroxymethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate 
• 1237714-73-6 ethyl 4-(bromomethyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylate 
• 1304062-29-0 C₂₃H₂₈F₃N₃O₄ 
• 1237714-89-4 N-((1R,3S)-3-hydroxycyclohexyl)-5-(4-(trifluoromethyl)phenyl)-4-(((S)-1,1,1-trifluoropropan-2-ylamino)methyl)isoxazole-3-carboxamide 
• 1237714-91-8 4-((cyclobutylmethylamino)methyl)-N-((1R,3S)-3-hydroxycyclohexyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1237715-01-3 4-((cyclopropylmethylamino)methyl)-N-((1R,3S)-3-hydroxycyclohexyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 
• 1237714-93-0 N-((1R,3S)-3-hydroxycyclohexyl)-4-((isobutylamino)methyl)-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxamide 

Relevant articles and documents

ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES

The present invention relates to isoxazole-3-carboxamide derivative having the general Formula I or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said isoxazole-3-carboxamide deriv

ISOXAZOLE DERIVATIVE HAVING AGONISTIC ACTIVITY AGAINST PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR

A compound of formula (I) : (wherein R1-R10 are each independently hydrogen, halogen, optionally substituted lower alkyl or the like, X1 is -O-, -S-, -NR11- (wherein R11 is hydrogen, lower alkyl or the like), -CR12R13CO-, -(CR12R13)mO-, -O(CR12R13)m- (wherein R12 and R13 are each independently hydrogen or lower alkyl and m is a integer between 1 and 3) or the like, X2 is a bond, -O-, -S-, -NR14- (wherein R14 is hydrogen, lower alkyl or the like, R14 and R6 can be taken together with the neighboring atom to form a ring) or -CR15R16-(wherein R15 and R16 are each independently hydrogen or lower alkyl, R15 and R6 or R10 can be taken together with the neighboring carbon atom to form a ring, R16 and R9 can be joined together to form a bond), X3 is COOR17, C( = NR17)NR18OR19 or the like), a pharmaceutically acceptable salt or a solvate thereof.