3-[Benzyloxy-(6-{3-[benzyloxy-(6-{3-[benzyloxy-(6-tert-butoxycarbonylamino-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Base Information

• Chemical Name: 3-[Benzyloxy-(6-{3-[benzyloxy-(6-{3-[benzyloxy-(6-tert-butoxycarbonylamino-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester
• CAS No.: 97222-30-5
• Molecular Formula: C₅₇H₇₉N₇O₁₄
• Molecular Weight: 1086.29
• Mol file: 97222-30-5.mol

Synonyms:3-[Benzyloxy-(6-{3-[benzyloxy-(6-{3-[benzyloxy-(6-tert-butoxycarbonylamino-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property of 3-[Benzyloxy-(6-{3-[benzyloxy-(6-{3-[benzyloxy-(6-tert-butoxycarbonylamino-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[Benzyloxy-(6-{3-[benzyloxy-(6-{3-[benzyloxy-(6-tert-butoxycarbonylamino-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 10 articles about 3-[Benzyloxy-(6-{3-[benzyloxy-(6-{3-[benzyloxy-(6-tert-butoxycarbonylamino-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(tert-butoxycarbonylamino)hexanoic acid (6404-29-1) → 3-[Benzyloxy-(6-{3-[benzyloxy-(6-{3-[benzyloxy-(6-tert-butoxycarbonylamino-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester (97222-30-5)

Guidance literature:

Multi-step reaction with 9 steps

1: 93 percent / ClCO₂Bu-i, Et₃N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h

2: 4 M HCl / dioxane / 2 h / Ambient temperature

3: 77 percent / Et₃N / dimethylformamide / 30 h / 30 °C

4: 97 percent / ClCO₂Bu-i, Et₃N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h

5: 4 M HCl / dioxane / 2 h / Ambient temperature

6: 93 percent / Et₃N / dimethylformamide / 30 h / 30 °C

7: 93 percent / ClCO₂Bu-i, Et₃N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h

8: 1 M NaOH / methanol / 5 h / Ambient temperature

9: N-ethyl-N'-(3-dimethylaminopropyl)carbodi-imide / 1.) -5 deg C, 2 h, 2.) 5 deg C, 12 h

With hydrogenchloride; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1039/c39850000183

Reference yield:

3-(benzyloxyamino)propanoic acid methyl ester (30204-31-0) → 3-[Benzyloxy-(6-{3-[benzyloxy-(6-{3-[benzyloxy-(6-tert-butoxycarbonylamino-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester (97222-30-5)

Guidance literature:

Multi-step reaction with 9 steps

1: 93 percent / ClCO₂Bu-i, Et₃N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h

2: 4 M HCl / dioxane / 2 h / Ambient temperature

3: 77 percent / Et₃N / dimethylformamide / 30 h / 30 °C

4: 97 percent / ClCO₂Bu-i, Et₃N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h

5: 4 M HCl / dioxane / 2 h / Ambient temperature

6: 93 percent / Et₃N / dimethylformamide / 30 h / 30 °C

7: 93 percent / ClCO₂Bu-i, Et₃N / 1.) -15 deg C, 5 h, 2.) r.t., 20 h

8: 1 M NaOH / methanol / 5 h / Ambient temperature

9: N-ethyl-N'-(3-dimethylaminopropyl)carbodi-imide / 1.) -5 deg C, 2 h, 2.) 5 deg C, 12 h

With hydrogenchloride; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

DOI:10.1039/c39850000183

Reference yield:

Boc-Ahe-(BzlO)Apr-Ahe-(BzlO)Apr-Ahe-(BzlO)Apr-OMe (97222-25-8) → 3-[Benzyloxy-(6-{3-[benzyloxy-(6-{3-[benzyloxy-(6-tert-butoxycarbonylamino-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionylamino}-hexanoyl)-amino]-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester (97222-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 M NaOH / methanol / 5 h / Ambient temperature

2: N-ethyl-N'-(3-dimethylaminopropyl)carbodi-imide / 1.) -5 deg C, 2 h, 2.) 5 deg C, 12 h

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol;

DOI:10.1039/c39850000183

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Boc-Ahe-(BzlO)Apr-Ahe-(BzlO)Apr-Ahe-(BzlO)Apr-OH

6-(tert-butoxycarbonylamino)hexanoic acid

3-(benzyloxyamino)propanoic acid methyl ester

Downstream raw materials:

5,16,27-Tris-benzyloxy-1,5,12,16,23,27-hexaaza-cyclotritriacontane-2,6,13,17,24,28-hexaone