Phosphoric acid 2-chloro-4-nitro-phenyl ester (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester

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Chemical Name:Phosphoric acid 2-chloro-4-nitro-phenyl ester (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester
CAS No.:115142-08-0
Molecular Formula:C₁₅H₁₅ClN₃O₁₁P
Molecular Weight:479.724
Hs Code.:

Phosphoric acid 2-chloro-4-nitro-phenyl ester (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Synonyms:Phosphoric acid 2-chloro-4-nitro-phenyl ester (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester

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Chemical Property of Phosphoric acid 2-chloro-4-nitro-phenyl ester (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester

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Technology Process of Phosphoric acid 2-chloro-4-nitro-phenyl ester (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester

There total 3 articles about Phosphoric acid 2-chloro-4-nitro-phenyl ester (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115142-23-9
Phosphoric acid 2-chloro-4-nitro-phenyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-(tetrahydro-pyran-2-yloxy)-2-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-3-yl ester

: 115142-08-0
Phosphoric acid 2-chloro-4-nitro-phenyl ester (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: With Amberlyst 15 ion-exchange resin; In water; for 0.5h; Ambient temperature;
DOI:10.1021/ja00223a031

Reference yield:

: 619-08-9
2-chloro-4-nitrophenol

: 115142-08-0
Phosphoric acid 2-chloro-4-nitro-phenyl ester (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaCl, POCl₃ / 1.) 90 deg C, 20 min 2.)110 deg C, 2 h

2: 1,2,4-triazole, triethylamine, pyridine / acetonitrile / 2 h / Ambient temperature

3: Amberlyst 15 ion-exchange resin / H₂O / 0.5 h / Ambient temperature

With pyridine; 1,2,4-Triazole; Amberlyst 15 ion-exchange resin; triethylamine; sodium chloride; trichlorophosphate; In water; acetonitrile;
DOI:10.1021/ja00223a031

Reference yield:

: 20056-43-3
2-chloro-4-nitrophenyl phosphorodichloridate

: 115142-08-0
Phosphoric acid 2-chloro-4-nitro-phenyl ester (2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2,4-triazole, triethylamine, pyridine / acetonitrile / 2 h / Ambient temperature

2: Amberlyst 15 ion-exchange resin / H₂O / 0.5 h / Ambient temperature

With pyridine; 1,2,4-Triazole; Amberlyst 15 ion-exchange resin; triethylamine; In water; acetonitrile;
DOI:10.1021/ja00223a031