5-Pyrimidinecarboxaldehyde, 4-amino-2,6-dimethyl- (9CI)

Base Information

• Chemical Name: 5-Pyrimidinecarboxaldehyde, 4-amino-2,6-dimethyl- (9CI)
• CAS No.: 76574-47-5
• Molecular Formula: C7H9 N3 O
• Molecular Weight: 151.168
• Hs Code.: 2933599090
• Mol file: 76574-47-5.mol

Synonyms:5-Pyrimidinecarboxaldehyde, 4-amino-2,6-dimethyl- (9CI)

Chemical Property of 5-Pyrimidinecarboxaldehyde, 4-amino-2,6-dimethyl- (9CI)

Chemical Property:

• PSA: 69.60000
• LogP: 0.41820
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2,6-dimethylpyrimidine-5-carbaldehyde >85% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinecarboxaldehyde, 4-amino-2,6-dimethyl- (9CI)

There total 3 articles about 5-Pyrimidinecarboxaldehyde, 4-amino-2,6-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-amino-2,6-dimethylpyrimidine-5-carbonitrile (34684-87-2) → 2,6-dimethyl-4-amino-5-pyrimidinecarbaldehyde (76574-47-5)

Guidance literature:

With formic acid; Reflux;

DOI:10.1021/acs.jafc.0c07701

Reference yield:

(1-ethoxyethylidene)malononitrile (5417-82-3) → 2,6-dimethyl-4-amino-5-pyrimidinecarbaldehyde (76574-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Na, EtOH / 2 h

2: H₂, HCO₂H / Raney nickel / 3 h / 2585.7 Torr / Ambient temperature

With formic acid; ethanol; hydrogen; sodium; nickel;

DOI:10.1021/jm00136a006

Reference yield:

(1-ethoxyethylidene)malononitrile (5417-82-3) → 2,6-dimethyl-4-amino-5-pyrimidinecarbaldehyde (76574-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium; ethanol / 0.5 h / 20 °C

2: formic acid / Reflux

With formic acid; ethanol; sodium;

DOI:10.1021/acs.jafc.0c07701

upstream raw materials:

4-amino-2,6-dimethylpyrimidine-5-carbonitrile

(1-ethoxyethylidene)malononitrile

Downstream raw materials:

6-(2,6-dichlorophenyl)-2,4-dimethylpyrido[2,3-d]-pyrimidin-7-amine

2,4-Dimethyl-6-o-tolyl-pyrido[2,3-d]pyrimidin-7-ylamine

4-Amino-5-bromomethyl-2,6-dimethylpyrimidine hydrobromide