34684-87-2

Basic information

• Product Name: 4-AMINO-5-CYANO-2,6-DIMETHYLPYRIMIDINE
• Synonyms: 5-Pyrimidinecarbonitrile, 4-amino-2,6-dimethyl- (6CI,7CI,9CI)
• CAS NO: 34684-87-2
• Molecular Formula: C₇H₈N₄
• Molecular Weight: 148.1686
• Product Categories: PYRIMIDINE
• Mol File: 34684-87-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 326°Cat760mmHg
• Flash Point: 151°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0.000221mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 4-AMINO-5-CYANO-2,6-DIMETHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-5-CYANO-2,6-DIMETHYLPYRIMIDINE(34684-87-2)
• EPA Substance Registry System: 4-AMINO-5-CYANO-2,6-DIMETHYLPYRIMIDINE(34684-87-2)

Safety Data

• Hazardous Substances Data: 34684-87-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 24, p. 5861, 1968 DOI: 10.1016/S0040-4020(01)96316-1

InChI:InChI=1/C7H8N4/c1-4-6(3-8)7(9)11-5(2)10-4/h1-2H3,(H2,9,10,11)

Upstream product

• 128199-32-6 2,4-dimethyl-6-oxo-1,6-dihydro-pyrimidine-5-carbonitrile 
• 7752-80-9 4-amino-5-bromo-2,6-dimethylpyrimidine 
• 124-42-5 acetamidine hydrochloride 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 143-37-3 acetamidine 
• 141-52-6 sodium ethanolate 
• 109-77-3 malononitrile 

Downstream Products

• 1202648-41-6 C₃₀H₃₇N₅O₆S 
• 1202648-40-5 C₃₀H₃₈N₆O₅S 
• 1201793-66-9 N-(4,5-dimethyl-3-isoxazolyl)-N-(methoxymethyl)-4'-[[(2,6-dimethyl-5-cyano-4-pyrimidinyl)amino]methyl]-2'-(ethoxymethyl)[1,1'-biphenyl]-2-sulfonamide 
• 124111-19-9 3-(4-amino-2,6-dimethyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazolium; dipicrate 
• 87118-49-8 4-Amino-5-bromomethyl-2,6-dimethylpyrimidine hydrobromide 
• 76574-92-0 6-(2,6-dichlorophenyl)-2,4-dimethylpyrido[2,3-d]-pyrimidin-7-amine 
• 76574-91-9 2,4-Dimethyl-6-o-tolyl-pyrido[2,3-d]pyrimidin-7-ylamine 
• 76574-47-5 2,6-dimethyl-4-amino-5-pyrimidinecarbaldehyde 
• 98337-38-3 2,6-Dimethyl-4-amino-5-aminomethyl-pyrimidin 

Relevant articles and documents

Design, Synthesis, and Antifungal Activity of 2,6-Dimethyl-4-aminopyrimidine Hydrazones as PDHc-E1 Inhibitors with a Novel Binding Mode

A series of novel 2,6-dimethyl-4-aminopyrimidine hydrazones 5 were rationally designed and synthesized as pyruvate dehydrogenase complex E1 (PDHc-E1) inhibitors. Compounds 5 strongly inhibited Escherichia coli (E. coli) PDHc-E1 (IC50 values 0.94-15.80 μM). As revealed by molecular docking, site-directed mutagenesis, enzymatic, and inhibition kinetic analyses, compounds 5 competitively inhibited PDHc-E1 and bound in a "straight"pattern at the E. coli PDHc-E1 active site, which is a new binding mode. In in vitro antifungal assays, most compounds 5 at 50 μg/mL showed more than 80% inhibition against the mycelial growth of six tested phytopathogenic fungi, including Botrytis cinerea, Monilia fructigena, Colletotrichum gloeosporioides, andBotryosphaeria dothidea. Notably, 5f and 5i were 1.8-380 fold more potent against M. fructigena than the commercial fungicides captan and chlorothalonil. In vivo, 5f and 5i controlled the growth of M. fructigena comparably to the commercial fungicide tebuconazole. Thus, 5f and 5i have potential commercial value for the control of peach brown rot caused by M. fructigena.

Pteridines. X. Some pyrimidopyrimidine isomers of triamterene.

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