(2S)-2-methyl-1-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

Base Information

Chemical Name:(2S)-2-methyl-1-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline
CAS No.:1290176-64-5
Molecular Formula:C₂₇H₂₃N₃O₅
Molecular Weight:469.497
Hs Code.:

Synonyms:(2S)-2-methyl-1-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-methyl-1-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

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Technology Process of (2S)-2-methyl-1-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

There total 7 articles about (2S)-2-methyl-1-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 200125-70-8
(S)-2-methyl-1,2,3,4-tetrahydroquinoline

: 3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl chloride

: 1290176-64-5
(2S)-2-methyl-1-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

Guidance literature:: In dichloromethane; at 20 ℃; for 6h; optical yield given as %de;
DOI:10.1016/j.tetasy.2010.12.017

Reference yield:

: 1780-19-4
1,2,3,4-tetrahydro-2-methylquinoline

: 3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl chloride

: (2R)-2-methyl-1-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

: 1290176-64-5
(2S)-2-methyl-1-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

: 200125-70-8
(S)-2-methyl-1,2,3,4-tetrahydroquinoline

: 1780-19-4,63430-95-5,74497-74-8
(R)-1,2,3,4-tetrahydroquinaldine

Guidance literature:: In dichloromethane; at -20 ℃; for 6h; optical yield given as %ee; stereoselective reaction;
DOI:10.1016/j.tetasy.2010.12.017

Reference yield:

: 22509-74-6
N-ethoxycarbonylphthalimide

: 1290176-64-5
(2S)-2-methyl-1-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-1,2,3,4-tetrahydroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / water / 20 °C

2: oxalyl dichloride / hexane; N,N-dimethyl-formamide; benzene / 6 h / 20 °C

3: dichloromethane / 6 h / 20 °C

With oxalyl dichloride; sodium carbonate; In hexane; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.tetasy.2010.12.017