200125-70-8Relevant articles and documents
Highly enantioselective hydrogenation of quinolines under solvent-free or highly concentrated conditions
Wang, Zhi-Jian,Zhou, Hai-Feng,Wang, Tian-Li,He, Yan-Mei,Fan, Qing-Hua
, p. 767 - 769 (2009)
The phosphine-free chiral cationic Ru(OTf)(TsDPEN)(η6- cymene) complex was found to be an efficient catalyst for the enantioselective hydrogenation of quinolines under more environmentally friendly solvent-free or highly concentrated conditions
Manganese-Catalyzed Asymmetric Hydrogenation of Quinolines Enabled by π–π Interaction**
Liu, Chenguang,Wang, Mingyang,Liu, Shihan,Wang, Yujie,Peng, Yong,Lan, Yu,Liu, Qiang
supporting information, p. 5108 - 5113 (2021/01/21)
The non-noble metal-catalyzed asymmetric hydrogenation of N-heteroaromatics, quinolines, is reported. A new chiral pincer manganese catalyst showed outstanding catalytic activity in the asymmetric hydrogenation of quinolines, affording high yields and enantioselectivities (up to 97 % ee). A turnover number of 3840 was reached at a low catalyst loading (S/C=4000), which is competitive with the activity of most effective noble metal catalysts for this reaction. The precise regulation of the enantioselectivity were ensured by a π–π interaction.
Enantiodivergent Synthesis of Chiral Tetrahydroquinoline Derivatives via Ir-Catalyzed Asymmetric Hydrogenation: Solvent-Dependent Enantioselective Control and Mechanistic Investigations
Han, Zhengyu,Liu, Gang,Yang, Xuanliang,Dong, Xiu-Qin,Zhang, Xumu
, p. 7281 - 7291 (2021/06/30)
Ir-catalyzed asymmetric hydrogenation of quinolines was developed, and both enantiomers of chiral tetrahydroquinoline derivatives could be easily obtained, respectively, in high yields with good enantioselectivities through the adjustment of reaction solvents (toluene/dioxane: up to 99% yield, 98% ee (R), TON = 680; EtOH: up to 99% yield, 94% ee (S), TON = 1680). It provided an efficient and simple synthetic strategy for the enantiodivergent synthesis of chiral tetrahydroquinolines, and gram-scale asymmetric hydrogenation proceeded well with low-catalyst loading in these two reaction systems. A series of deuterium-labeling experiments, control experiments, and 1H NMR and electrospray ionization-mass spectrometry experiments have been conducted, and a reasonable and possible reaction process was revealed on the basis of these useful observations.
DUAL KINASE-BROMODOMAIN INHIBITORS
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Page/Page column 92; 124, (2021/12/12)
Provided herein are compounds of Formula (I) that are dual inhibitors of kinases and bromo-domain proteins. The disclosure also relates to pharmaceutical compositions containing such compounds, methods for using such compounds in the treatment of cancers, particularly, the treatment of multiple myeloma cancers, and to related uses.
