2-(4-methoxyphenyl)-5-methyl-3H-imidazole-4-carboxylic acid (1-hydroxymethyl-2-phenylethyl)amide

Base Information

Chemical Name:2-(4-methoxyphenyl)-5-methyl-3H-imidazole-4-carboxylic acid (1-hydroxymethyl-2-phenylethyl)amide
CAS No.:618904-95-3
Molecular Formula:C₂₁H₂₃N₃O₃
Molecular Weight:365.432
Hs Code.:

Synonyms:2-(4-methoxyphenyl)-5-methyl-3H-imidazole-4-carboxylic acid (1-hydroxymethyl-2-phenylethyl)amide

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Chemical Property of 2-(4-methoxyphenyl)-5-methyl-3H-imidazole-4-carboxylic acid (1-hydroxymethyl-2-phenylethyl)amide

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Technology Process of 2-(4-methoxyphenyl)-5-methyl-3H-imidazole-4-carboxylic acid (1-hydroxymethyl-2-phenylethyl)amide

There total 3 articles about 2-(4-methoxyphenyl)-5-methyl-3H-imidazole-4-carboxylic acid (1-hydroxymethyl-2-phenylethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 618904-94-2
{[2-(4-methoxyphenyl)-5-methyl-3H-imidazole-4-carbonyl]amino}-phenylacetic acid methyl ester

: 618904-95-3
2-(4-methoxyphenyl)-5-methyl-3H-imidazole-4-carboxylic acid (1-hydroxymethyl-2-phenylethyl)amide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ol035455i

Reference yield:

: 62973-00-6
2-(3-oxo-butyrylamino)-3-phenylpropionic acid methyl ester

: 618904-95-3
2-(4-methoxyphenyl)-5-methyl-3H-imidazole-4-carboxylic acid (1-hydroxymethyl-2-phenylethyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / NaNO₂ / acetic acid; H₂O / 0.25 h / 0 °C

2: 63 percent / Et₃N / acetonitrile / 1.5 h / 80 °C

3: 100 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; sodium nitrite; In tetrahydrofuran; water; acetic acid; acetonitrile;
DOI:10.1021/ol035455i

Reference yield:

: 618904-93-1
2-(2-hydroxyimino-3-oxo-butyrylamino)-3-phenylpropionic acid methyl ester

: 618904-95-3
2-(4-methoxyphenyl)-5-methyl-3H-imidazole-4-carboxylic acid (1-hydroxymethyl-2-phenylethyl)amide

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / Et₃N / acetonitrile / 1.5 h / 80 °C

2: 100 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol035455i