(R)-3-((S,E)-6-nitro-5-phenyl-2-((triethylsilyl)oxy)hex-2-enoyl)-4-phenyloxazolidin-2-one

Base Information

Chemical Name:(R)-3-((S,E)-6-nitro-5-phenyl-2-((triethylsilyl)oxy)hex-2-enoyl)-4-phenyloxazolidin-2-one
CAS No.:1260511-20-3
Molecular Formula:C₂₇H₃₄N₂O₆Si
Molecular Weight:510.662
Hs Code.:

Synonyms:(R)-3-((S,E)-6-nitro-5-phenyl-2-((triethylsilyl)oxy)hex-2-enoyl)-4-phenyloxazolidin-2-one

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Chemical Property of (R)-3-((S,E)-6-nitro-5-phenyl-2-((triethylsilyl)oxy)hex-2-enoyl)-4-phenyloxazolidin-2-one

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Technology Process of (R)-3-((S,E)-6-nitro-5-phenyl-2-((triethylsilyl)oxy)hex-2-enoyl)-4-phenyloxazolidin-2-one

There total 5 articles about (R)-3-((S,E)-6-nitro-5-phenyl-2-((triethylsilyl)oxy)hex-2-enoyl)-4-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1092383-34-0
(R)-1-(2-oxo-4-phenyloxazolidin-3-yl)-2-(triethylsilyl)ethane-1,2-dione

: 102-96-5
(2-nitroethenyl)benzene

: 1826-67-1
vinyl magnesium bromide

: 1260511-20-3
(R)-3-((S,E)-6-nitro-5-phenyl-2-((triethylsilyl)oxy)hex-2-enoyl)-4-phenyloxazolidin-2-one

Guidance literature:: In toluene; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201003470

Reference yield:

: 90319-52-1,7480-32-2
(4R)-phenyl-2-oxazolidinone

: 1260511-20-3
(R)-3-((S,E)-6-nitro-5-phenyl-2-((triethylsilyl)oxy)hex-2-enoyl)-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; copper dichloride; oxygen; pyridine / toluene / 22 h / 70 °C / 760.05 Torr / Inert atmosphere

2: sodium periodate; ruthenium (IV) oxide monohydrate / dichloromethane; acetonitrile; water / 3 h / 20 °C / Inert atmosphere

3: toluene / 1 h / -78 - 23 °C / Inert atmosphere

With pyridine; sodium periodate; ruthenium (IV) oxide monohydrate; oxygen; sodium hydrogencarbonate; copper dichloride; In dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/acs.joc.5b02693

Reference yield:

: 1092383-26-0
(R)-4-phenyl-3-((triethylsilyl)ethynyl)oxazolidin-2-one

: 1260511-20-3
(R)-3-((S,E)-6-nitro-5-phenyl-2-((triethylsilyl)oxy)hex-2-enoyl)-4-phenyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium periodate; ruthenium (IV) oxide monohydrate / dichloromethane; acetonitrile; water / 3 h / 20 °C / Inert atmosphere

2: toluene / 1 h / -78 - 23 °C / Inert atmosphere

With sodium periodate; ruthenium (IV) oxide monohydrate; In dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/acs.joc.5b02693