(2-(4-methoxyphenyl)benzo[b]thiophene-3-yl)-(6-chloropyrid-3-yl)ketone

Base Information

• Chemical Name: (2-(4-methoxyphenyl)benzo[b]thiophene-3-yl)-(6-chloropyrid-3-yl)ketone
• CAS No.: 193964-29-3
• Molecular Formula: C₂₁H₁₄ClNO₂S
• Molecular Weight: 379.867
• Mol file: 193964-29-3.mol

Synonyms:(2-(4-methoxyphenyl)benzo[b]thiophene-3-yl)-(6-chloropyrid-3-yl)ketone

Chemical Property of (2-(4-methoxyphenyl)benzo[b]thiophene-3-yl)-(6-chloropyrid-3-yl)ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-(4-methoxyphenyl)benzo[b]thiophene-3-yl)-(6-chloropyrid-3-yl)ketone

There total 1 articles about (2-(4-methoxyphenyl)benzo[b]thiophene-3-yl)-(6-chloropyrid-3-yl)ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

6-Chloronicotinoyl chloride (58757-38-3) + 2-(4-methoxyphenyl)benzo[b]thiophene (27884-09-9) → (2-(4-methoxyphenyl)benzo[b]thiophene-3-yl)-(6-chloropyrid-3-yl)ketone (193964-29-3)

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; at 0 ℃; for 5h;

DOI:10.1021/jm9903388

Reference yield: 99.0%

1-pyrrolidineethanol (2955-88-6) + (2-(4-methoxyphenyl)benzo[b]thiophene-3-yl)-(6-chloropyrid-3-yl)ketone (193964-29-3) → 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 6-[2-(1-pyrrolidinyl)ethoxy]pyrid-3-yl ketone (193964-30-6)

Guidance literature:

1-pyrrolidineethanol; With sodium; In xylene; at 50 ℃;

(2-(4-methoxyphenyl)benzo[b]thiophene-3-yl)-(6-chloropyrid-3-yl)ketone; In xylene; at 50 ℃; for 2h; Further stages.;

DOI:10.1021/jm9903388

Reference yield:

(2-(4-methoxyphenyl)benzo[b]thiophene-3-yl)-(6-chloropyrid-3-yl)ketone (193964-29-3) → {2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-benzo[b]thiophen-3-yl}-[6-(2-pyrrolidin-1-yl-ethoxy)-pyridin-3-yl]-methanone

Guidance literature:

Multi-step reaction with 3 steps

1.1: Na / xylene / 50 °C

1.2: 99 percent / xylene / 2 h / 50 °C

2.1: 89 percent / AlCl₃; EtSH / CH₂Cl₂ / 2 h / 20 °C

3.1: 84 percent / Cs₂CO₃ / dimethylformamide / 16 h / 80 °C

With aluminium trichloride; sodium; caesium carbonate; ethanethiol; In dichloromethane; N,N-dimethyl-formamide; xylene; 1.1: deprotonation / 1.2: Alkylation / 2.1: demethylation / 3.1: Alkylation;

DOI:10.1021/jm9903388

upstream raw materials:

6-Chloronicotinoyl chloride

2-(4-methoxyphenyl)benzo[b]thiophene

Downstream raw materials:

2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 6-[2-(1-pyrrolidinyl)ethoxy]pyrid-3-yl ketone

2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl 6-[2-(1-pyrrolidinyl)ethoxy]pyrid-3-yl ketone