N₁-methyl-N₁-(2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzene-1,3-diamine

Base Information

• Chemical Name: N₁-methyl-N₁-(2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzene-1,3-diamine
• CAS No.: 1402747-91-4
• Molecular Formula: C₁₇H₂₄N₆
• Molecular Weight: 312.418

Synonyms:N₁-methyl-N₁-(2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzene-1,3-diamine

Chemical Property of N₁-methyl-N₁-(2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzene-1,3-diamine

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Technology Process of N₁-methyl-N₁-(2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzene-1,3-diamine

There total 5 articles about N₁-methyl-N₁-(2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzene-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N,2-dimethyl-6-(4-methylpiperazin-1-yl)-N-(3-nitrophenyl)pyrimidin-4-amine (1402747-90-3) → N1-methyl-N1-(2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzene-1,3-diamine (1402747-91-4)

Guidance literature:

With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; for 2h; Reflux;

DOI:10.1111/cbdd.12198

Reference yield:

6-chloro-N,2-dimethyl-N-(3-nitrophenyl)pyrimidin-4-amine (1402747-86-7) → N1-methyl-N1-(2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzene-1,3-diamine (1402747-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 0.33 h / 140 °C / Inert atmosphere

2: iron; ammonium chloride / water; ethanol; tetrahydrofuran / 2 h / Reflux

With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;

DOI:10.1111/cbdd.12198

Reference yield:

1-methyl-piperazine (109-01-3) → N1-methyl-N1-(2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)benzene-1,3-diamine (1402747-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 0.33 h / 140 °C / Inert atmosphere

2: iron; ammonium chloride / water; ethanol; tetrahydrofuran / 2 h / Reflux

With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;

DOI:10.1111/cbdd.12198

upstream raw materials:

6-chloro-N,2-dimethyl-N-(3-nitrophenyl)pyrimidin-4-amine

N,2-dimethyl-6-(4-methylpiperazin-1-yl)-N-(3-nitrophenyl)pyrimidin-4-amine

1-methyl-piperazine

3-nitro-aniline

Downstream raw materials:

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(methyl(2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)amino)phenyl)urea

C₂₄H₂₇N₇O₄*ClH

1-(3-chloro-4-fluorophenyl)-3-(3-(methyl(2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl)amino)phenyl)urea

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